Probing the immune responses to nanoparticles across environmental species. A perspective of the EU Horizon 2020 project PANDORA
| Autor: | Pinsino, Annalisa, Bastús, Neus G., Busquets-Fité, Martí, Canesi, Laura, Cesaroni, Paola, Drobne, Damjana, Duschl, Albert, Ewart, Marie-Ann, Gispert, Ignasi, Horejs-Hoeck, Jutta, Italiani, Paola, Kemmerling, Birgit, Kille, Peter, Prochazkova, Petra, Puntes, Víctor F., Spurgeon, David J., Svendsen, Claus, Wilde, Colin J., Boraschi, Diana |
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| Přispěvatelé: | European Commission, Ministry of Education, Youth and Sports (Czech Republic) |
| Rok vydání: | 2020 |
| Předmět: |
Engineered nanomaterials
Comparative analysis environmental health Experimental methodology engineered nanomaterials Nanoparticle exposures Biology and Microbiology Terrestrial invertebrate Stem cell differentiation nanoparticles Homeostatic mechanism innate immunity Environmental species nanosafety |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname Environmental science. Nano (Online) (2020). doi:10.1039/D0EN00732C info:cnr-pdr/source/autori:Annalisa Pinsino; Neus G. Bastús; Martí Busquets-Fité; Laura Canesi; Paola Cesaroni; Damjana Drobne; Albert Duschl; Marie-Ann Ewart; Ignasi Gispert; Jutta Horejs-Hoeck; Paola Italiani; Birgit Kemmerling; Peter Kille; Petra Procházková; Victor F. Puntes; David J. Spurgeon; Claus Svendsen; Colin J. Wilde; Diana Boraschi/titolo:Probing the immune responses to nanoparticles across environmental species. A perspective of the EU Horizon 2020 project PANDORA/doi:10.1039%2FD0EN00732C/rivista:Environmental science. Nano (Online)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume |
| DOI: | 10.1039/D0EN00732C |
| Popis: | Understanding how engineered nanomaterials affect immune responses of living organisms requires a strong collaborative effort between immunologists, toxicologists, ecologists, physiologists, inorganic chemists, nanomaterial scientists and experts in law and risk management. This perspective aims to provide a new viewpoint on the interaction between engineered nanomaterials and the immune defensive systems across living species, gained within the EU Horizon 2020 project PANDORA. We consider the effects of nanoparticle exposure on immune functions in plants, marine and terrestrial invertebrates and their relation to the current state of knowledge for vertebrates (in particular humans). These studies can shed light on the broader perspective of defensive and homeostatic mechanisms (immunity, inflammation, stress responses, microbiota, stem cell differentiation) suggesting ways to: i) perform a comparative analysis of the nanoparticle impact on immunity across model organisms; ii) inspire best practices in experimental methodologies for nanosafety/nanotoxicity studies; iii) regroup and harmonise fragmented research activities; iv) improve knowledge transfer strategies and nano-security; v) propose innovative tools and realistic solutions, thereby helping in identifying future research needs and tackling their challenges. This work is based on the EU Commission H2020 project PANDORA (GA 671881) that has supported the studies of all authors. The authors wish to acknowledge the EM Facility of CAS (Prague, Czech Republic; supported by the project LO1509 of the Ministry of Education, Youth and Sports) for providing the electron microscopy images. A special thanks to Giuliana Donini (EU Commission, Bruxelles, Belgium), who has expertly supported this project throughout all stages of its development. |
| Databáze: | OpenAIRE |
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