| Autor: |
Bart Van der Auwera, Waeyenberghe, C., Franciscus Schuit, Harry Heimberg, Christina Vandewalle, Frans Gorus, Flament, J. |
| Přispěvatelé: |
Pathologic Biochemistry and Physiology, Medical Biochemistry, Institute for Clinical Research |
| Jazyk: |
angličtina |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Vrije Universiteit Brussel |
| Popis: |
The human leukocyte antigen (HLA) class II genotype DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 has been identified as a marker strongly predisposing to insulin-dependent diabetes mellitus (IDDM) in Caucasian populations. Its frequency in control populations (1-3%) is still, however, 1 order of magnitude higher than the prevalence of IDDM, suggesting that its penetrance can be modified by protective factors, In this study we searched for such a factor in the DRB1 locus by studying DRB1*04 polymorphism in 174 European Caucasian IDDM patients and 73 nondiabetic control subjects, all sharing the HLA-DR3/DR4 phenotype. Significant protection was encoded by the DRB1*0403 allele, which was observed in 5 of 49 control subjects (10%) and none of 171 IDDM patients (0%) with the DQA1*0301-DQB1* 0302/DQA1*0501-DQB1*0201 genotype (RR = 0.02 [0.01-0.18], P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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