The Antidiarrhoeal Activity of the Aqueous Root Extract of Aristolochia ringens (Vahl.) Aristolochiaceae
| Autor: | Adeyemi, O. O., Aigbe, F. R., Badru, O. A. |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Nigerian Quarterly Journal of Hospital Medicine; Vol 22, No 1 (2012); 29-33 Scopus-Elsevier |
| ISSN: | 0189-2657 |
| Popis: | Background: Aristolochia ringens, an ornamental plant native to tropical America that now grows in a number of African countries has been reported to be used in African traditional medicine for the management of snake bite venom, gastrointestinal disturbances, rheumatoicd arthritis and insomnia among others.Objective: Based on its use in traditional African medicine, the antidiarrhoeal activity of the aqueous root extract of Aristolochia ringens (AR) was evaluated to determine the pharmacological basis of its use in the management of diarrhoea.Methods: Normal and castor oil (CO) induced intestinal transit, castor oil induced diarrhoea, gastric emptying and enteropooling models were carried out in mice and rats. Preliminary phytochemical screening and acute toxicity tests were also carried out.Results: AR (100-400 mg/kg, p.o.) produced a dosedependent and significant decrease in normal and castor oil-induced intestinal transit compared to the vehicle group. This effect was significantly (p |
| Databáze: | OpenAIRE |
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