A Model of Vascular Tumor Response to Chemotherapy Combined with Anti-Angiogenic Therapy
| Autor: | Bacelar, Flora S. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | Flora S. Bacelar... et al. Angiogenesis is acknowledged as an essential mechanism for tumor spreading and metastasis of neoplastic diseases. Consequently, anti-angiogenic therapy has been proposed as a complementary or perhaps an alternative strategy to the traditional cytotoxic therapies. This work considers a model of ordinary di®erential equations that describe the dynamics of tumors at the vascular stage (after the angiogenic process has been triggered), under the action of chemical and anti-angiogenic ther- apies. Due to the increase of endothelial cells at the vascular stage, the cancer state prevails over the internal state in the no treatment situation. Results from the lo- cal stability analysis and numerical integration, indicate that the combination of chemotherapy and anti-angiogenic therapy is the best strategy to eliminate the tu- mor, reducing the cytotoxic e®ect. At a ¯xed infusion rate, the cure state may be reached when the combined therapy is considered but not for the anti-angiogenic therapy only. On the other hand, pure chemotherapy efectively destroys the tumor, but only when higher infusion doses are applied. Acknowledgments: STRP, RFSA thank CNPq for partial supporting the re- search |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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