Synthesis of potentially photoactivatable coumarin derivatives via a 1,3-dipolar cycloaddition

Autor: Chenot, Elodie-Denise, Rodriguez-Dominguez, Juan Carlos, Hannewald, Paul, Comel, Alain, Kirsch, Gilbert
Přispěvatelé: ProdInra, Migration, Université Paul Verlaine - Metz (UPVM)
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Zdroj: Journal of Heterocyclic Chemistry
Journal of Heterocyclic Chemistry, Wiley, 2008, 45 (5), pp.1429-1435
ISSN: 0022-152X
1943-5193
Popis: A copper (I)-catalyzed 1,3-dipolar cycloaddition reaction was used to prepare a series of mono and disubstituted 1,2,3-triazolyl-coumarins using a 1,3-cycloaddition ("Click Chemistry"). Starting coumarins were synthesized using classical or modified Pechmann's reaction. The propargyl group was introduced as either propargylether or as a propargylamide. Azides were prepared in a three steps procedure. Cycloaddition products, containing a coumarin and a photoactivatable moiety, were obtained in good yields.
Databáze: OpenAIRE
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