Insulin-Induced Microvascular Recruitment in Skin and Muscle are Related and Both are Associated with Whole-Body Glucose Uptake

Autor: Meijer, R.I., de Boer, M.P., Groen, M.R., Eringa, E.C., Rattigan, S., Barrett, E.J., Smulders, Y.M., Serné, E.H.
Přispěvatelé: Integrative Neurophysiology, Internal medicine, Physiology, ICaR - Circulation and metabolism
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Microcirculation, 19(6), 494-500. Wiley-Blackwell
Meijer, R I, de Boer, M P, Groen, M R, Eringa, E C, Rattigan, S, Barrett, E J, Smulders, Y M & Serné, E H 2012, ' Insulin-Induced Microvascular Recruitment in Skin and Muscle are Related and Both are Associated with Whole-Body Glucose Uptake ', Microcirculation, vol. 19, no. 6, pp. 494-500 . https://doi.org/10.1111/j.1549-8719.2012.00174.x
ISSN: 1073-9688
Popis: Objective: Insulin-induced capillary recruitment is considered a determinant of insulin-mediated glucose uptake. Insulin action on the microvasculature has been assessed in skin; however, there is concern as to whether the vascular responses observed in skin reflect those in the muscle. We hypothesized that insulin-induced capillary recruitment in skin would correlate with microvascular recruitment in muscle in a group of subjects displaying a wide variation in insulin sensitivity. Methods: Capillary recruitment in skin was assessed using capillary videomicroscopy, and skeletal muscle microvascular recruitment (i.e., increase in MBV) was studied using CEU in healthy volunteers (n=18, mean age: 30.6±11.1years). Both microvascular measurements were performed during saline infusion, and during a hyperinsulinemic euglycemic clamp. Results: During hyperinsulinemia, capillary recruitment in skin was augmented from 58.1±18.2% to 81.0±23.9% (p
Databáze: OpenAIRE
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