Farmaceutske forme željeza u dodacima prehrani

Autor: Lejla Dedić, Ivan Vukoja, Midhat Jašić, Daniela Čačić-Kenjerić, Ines Banjari
Přispěvatelé: Jerković, Igor, Šubarić, Drago, Jašić, Midhat
Jazyk: chorvatština
Rok vydání: 2018
Předmět:
Zdroj: Hrana u zdravlju i bolesti : znanstveno-stručni časopis za nutricionizam i dijetetiku
Volume Specijalno izdanje
Issue 11. Štamparovi dani
ISSN: 2233-1220
2233-1239
Popis: Donedavno najviše korišten preparat željeza je bio željezo sulfat, a danas se sve više koriste preparati gdje je želejezo vezano vezan u komplekse sa organskim spojevima. To poboljšava kvalitetu i bio-raspoloživost farmaceutskih formi željeza u lijekovima i dodacima prehrani. Takvi preparati koriste se kao lijekovi ili dodatci prehrani kod anemije. Cilj rada je bio analizrati raspoložive znanstvene informacija, kao i podatake iz tržišne ponude doda-taka prehrani koje sadrže željezo, o njihovom kemijskom sastavu, farmaceutskim formama i bio-raspoloživosti. U formulacijama dodataka prehrani sa željezom se najčešće koriste : željezo (II) fumarat, željezo (III) hidroksid u ugljikohidratnom polimeru - polimaltozi, kompleks željezo (III) hidroksida sa saharozom, suspenzija željezo (III) protein sukcinilata, željezo (II) glukonat kao i forme željeza porijeklom iz he-moglobina. U tim preparatima se nalazi u dvovalentnom i trovalentnom obliku. Zbog bolje iskoristivosti formulacije preparata željeza često sadrže vitamine kao što su askorbinska kiselina, cijanokobalamin, folna kiselina i drugi. Najčešće su dodaci u obliku kapsula i filmom oblože-nih tableta, a postoje i preparati u tekućoj formi. Forma primjene dodataka prehrani treba da se prilagodi načelima individualne prehrane i integrativne medicine, tako da se doze preparata i dijete trebaju međusobno harmonizirati. Doza dodataka prehrani se određuje na osnovu procjene zdravstvenog i prehrambenog statusa kao i drugih čimbenika. Danas se koriste različite farmaceutske forme željeza u dodacima prehrani kako po hemijskom sastavu tako i farmaceutski dozirni oblici što omogućava bolje rezultate njihove primjene u praksi.
Until recently, the most commonly used iron preparation was iron sulfate, and today it is increasingly used preparations where iron is bound into complexes with organic compounds. This improves the quality and bioavailability of iron pharmaceutical forms in medicines and dietary supplements. These preparations used as medicines or dietary supplements for anemia. The aim of the paper was to analyze the available scientific information, as well as the data from the market supply of iron supplements, its chemical composition, pharmaceutical forms and bioavailability. The most commonly used formulations in iron supplementation are: iron (II) fumarate, iron (III) hydroxide in carbohydrate polymer - polymaltose, complex of iron (III) hydroxide with sucrose, suspension of iron (III) protein succinylate, iron (II) gluconate and forms of iron originating from hemoglobin. In these preparations iron is in two valence and trivalent form. For better utilization, iron formulations often contain vitamins such as ascorbic acid, cyanocobalamin, folic acid and others. Most often, supplements are in the form of capsules and film-coated tablets, and there are preparations in liquid form. The form of administration of dietary supplements should be adapted to the principles of individual nutrition and integrative medicine, so that the doses of the preparation and diet should be harmonized. The dose of the dietary supplement is determined on the basis of an assessment of health and nutritional status as well as other factors. Today, various pharmaceutical forms of iron are used in dietary supplements, both in chemical composition and pharmaceutical dosage forms, which enables better results of their practical application.
Databáze: OpenAIRE
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