| Autor: |
Witteveen, J. E., Lierop, A. H., Hamdy, N. A. T., Papapoulos, S. E. |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
European Journal of Endocrinology, 163(5), 833-837 |
| Popis: |
Objective: In vitro and in vivo studies in animal models have shown that parathyroid hormone (PTH) inhibits the expression of the SOST gene, which encodes sclerostin, an osteocyte-derived negative regulator of bone formation. We tested the hypothesis that chronic PTH excess decreases circulating sclerostin in humans. Design: We studied 25 patients with elevated serum PTH concentrations due to primary hyperparathyroidism (PHPT) and 49 patients cured from PHPT after successful parathyroidectomy (PTx; euparathyroid controls (EuPTH)). Methods: We measured plasma PTH and serum sclerostin levels and the serum markers of bone turnover alkaline phosphatase, P1NP, and beta-CTX. Results: As expected by the design of the study, mean plasma PTH was significantly higher(P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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