Clinical Presentation of Coronavirus Disease 2019 (COVID-19) in Pregnant and Recently Pregnant People
| Autor: | Afshar, Yalda, Gaw, Stephanie L, Flaherman, Valerie J, Chambers, Brittany D, Krakow, Deborah, Berghella, Vincenzo, Shamshirsaz, Alireza A, Boatin, Adeline A, Aldrovandi, Grace, Greiner, Andrea, Riley, Laura, Boscardin, W John, Jamieson, Denise J, Jacoby, Vanessa L, Pregnancy CoRonavIrus Outcomes RegIsTrY (PRIORITY) Study |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Clinical Trials and Supportive Activities Vaccine Related Paediatrics and Reproductive Medicine Young Adult Betacoronavirus Risk Factors Pregnancy Clinical Research Biodefense Humans Viral Prospective Studies Obstetrics & Reproductive Medicine Pandemics Lung SARS-CoV-2 Prevention Infectious COVID-19 Pneumonia Pregnancy CoRonavIrus Outcomes RegIsTrY (PRIORITY) Study United States Pregnancy Complications Good Health and Well Being Emerging Infectious Diseases Infectious Diseases Pneumonia & Influenza Female Symptom Assessment Coronavirus Infections Infection |
| Zdroj: | Obstetrics and gynecology, vol 136, iss 6 |
| Popis: | ObjectiveTo describe the clinical presentation, symptomology, and disease course of coronavirus disease 2019 (COVID-19) in pregnancy.MethodsThe PRIORITY (Pregnancy CoRonavIrus Outcomes RegIsTrY) study is an ongoing nationwide prospective cohort study of people in the United States who are pregnant or up to 6 weeks postpregnancy with known or suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We analyzed the clinical presentation and disease course of COVID-19 in participants who tested positive for SARS-CoV-2 infection and reported symptoms at the time of testing.ResultsOf 991 participants enrolled from March 22, 2020, until July 10, 2020, 736 had symptoms of COVID-19 at the time of testing; 594 tested positive for SARS-CoV-2 infection and 142 tested negative in this symptomatic group. Mean age was 31.3 years (SD 5.1), and 37% will nulliparous. Ninety-five percent were outpatients. Participants who tested positive for SARS-CoV-2-infection were a geographically diverse cohort: 34% from the Northeast, 25% from the West, 21% from the South, and 18% from the Midwest. Thirty-one percent of study participants were Latina, and 9% were Black. The average gestational age at enrollment was 24.1 weeks, and 13% of participants were enrolled after pregnancy. The most prevalent first symptoms in the cohort of patients who tested positive for SARS-CoV-2 infection were cough (20%), sore throat (16%), body aches (12%), and fever (12%). Median time to symptom resolution was 37 days (95% CI 35-39). One quarter (25%) of participants who tested positive for SARS-CoV-2 infection had persistent symptoms 8 or more weeks after symptom onset.ConclusionCOVID-19 has a prolonged and nonspecific disease course during pregnancy and in the 6 weeks after pregnancy.Clinical trial registrationClinicalTrials.gov, NCT04323839. |
| Databáze: | OpenAIRE |
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