Special features of the DNA-hydrolyzing activity of the antibodies in systemic lupus erythematosus

Autor:	Nevzorova T., Temnikov D., Vinter V.
Rok vydání:	2003
Předmět:	Systemic lupus erythematosus Abzymes IgG DNA hydrolysis Polyclonal catalytic antibodies
Zdroj:	SCOPUS03209725-2003-68-12-SID1542638016 SCOPUS00062979-2003-68-12-SID0742285862
Popis:	Two types of IgG anti-DNA antibodies exhibiting DNA-hydrolyzing activity have been isolated from blood serum of patients with systemic lupus erythematosus. This DNase activity of antibodies differs from serum DNases by the non-processive mode, temperature resistance, pH optimum, and the rate of DNA hydrolysis. It is suggested that the anti-DNA anti-body molecule possessing DNase activity contains two sites: one site determines specificity of antibody-DNA interaction, whereas the other is responsible for manifestation of the catalytic activity.
Databáze:	OpenAIRE
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