Hippocampal atrophy varies by neuropsychologically defined MCI among men in their 50s
| Autor: | Jak, Amy J, Panizzon, Matthew S, Spoon, Kelly M, Fennema-Notestine, Christine, Franz, Carol E, Thompson, Wesley K, Jacobson, Kristen C, Xian, Hong, Eyler, Lisa T, Vuoksimaa, Eero, Toomey, Rosemary, Lyons, Michael J, Neale, Michael C, Tsuang, Ming T, Dale, Anders M, Kremen, William S |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Aging Clinical Sciences neuropsychology Neuropsychological Tests Neurodegenerative Alzheimer's Disease Hippocampus Diagnostic Radiology Behavioral and Social Science Acquired Cognitive Impairment Humans Alzheimer's Disease including Alzheimer's Disease Related Dementias Mental Competency Cognitive Dysfunction Longitudinal Studies Intelligence Tests Prevention Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Organ Size Middle Aged Magnetic Resonance Imaging United States MCI Brain Disorders Early Diagnosis Geriatrics Disease Progression Linear Models Public Health and Health Services Biomedical Imaging Dementia Cognitive Sciences Atrophy MRI |
| Zdroj: | Jak, AJ; Panizzon, MS; Spoon, KM; Fennema-Notestine, C; Franz, CE; Thompson, WK; et al.(2015). Hippocampal atrophy varies by neuropsychologically defined MCI among men in their 50s. American Journal of Geriatric Psychiatry, 23(5), 456-465. doi: 10.1016/j.jagp.2014.08.011. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/4sx0s476 The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, vol 23, iss 5 |
| DOI: | 10.1016/j.jagp.2014.08.011. |
| Popis: | © 2015 American Association for Geriatric Psychiatry. Objective In an effort to address earliest detection of mild cognitive impairment (MCI), we examined hippocampal volumes and atrophy in middle-aged men to explore neuroanatomical support for different neuropsychological definitions of MCI. Methods 460 men aged 51-60 years underwent neuropsychological testing and MRI. MCI was defined according to five criteria sets. MRI-derived hippocampal volume and hippocampal occupancy (HOC) were obtained via FreeSurfer. Statistical analyses were performed using linear mixed models. Results Differences in HOC between normal cognitive functioning, amnestic, and non-amnestic MCI were observed using MCI criteria that required one impaired (>1.5 SD) cognitive measure in a given cognitive domain or a cognitive composite score method with a cut-point 2 SD below the mean. Differences in standard hippocampal volume were only found between normal and amnestic presentations and only when using the composite score method. Conclusion Results provide empirical support for detection of pre-MCI in younger cohorts. Convergence of neuropsychological and neuroanatomical data, particularly HOC (as opposed to standard cross-sectional volume), supports early identification of MCI as defined by some neuropsychological criteria. |
| Databáze: | OpenAIRE |
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