Templated nucleotide addition and immunoglobulin JH-gene utilization in t(11;14) junctions: Implications for the mechanism of translocation and the origin of mantle cell lymphoma

Autor: Welzel, N., Le, T., Marculescu, R., Mitterbauer, G., Chott, A., Pott, C., Kneba, M., Du, M. -Q, Kusec, R., Drach, J., Raderer, M., Christine Mannhalter, Lechner, K., Nadel, B., Jaeger, U.
Jazyk: angličtina
Rok vydání: 2001
Předmět:
Zdroj: Scopus-Elsevier
Popis: The t(11;14) (q13;q32) between the BCL-1 and immunoglobulin heavy chain gene (Ig-H) loci in mantle cell lymphomy (MCL) are believed to be mediated by the mechanism of V(D)J recombination similar to the t(14;18) in follicular lymphoma. We have recently shown that the t(14;18) event creates staggered double-strand breaks in the BC-2 locus, and that the t(14;18) junctions contain templated nucleotide insertions (T-nucleotides)...
Databáze: OpenAIRE