How Hand Osteoarthritis, Comorbidity, and Pain Interact to Determine Functional Limitation in Older People: Observations From the European Project on OSteoArthritis Study

Autor: Siviero, P, Zambon, S, Limongi, F, Castell, MV, Cooper, C, Deeg, DJH, Denkinger, MD, Dennison, EM, Edwards, MH, Gesmundo, A, Otero, Á, Pedersen, NL, Peter, R, Queipo, R, Timmermans, EJ, van Schoor, NM, Maggi, S
Přispěvatelé: Epidemiology and Data Science, EMGO - Musculoskeletal health
Jazyk: angličtina
Rok vydání: 2016
Zdroj: Siviero, P, Zambon, S, Limongi, F, Victoria Castell, M, Cooper, C, Deeg, D J H, Denkinger, M D, Dennison, E M, Edwards, M H, Gesmundo, A, Otero, A, Pedersen, N L, Peter, R, Queipo, R, Timmermans, E J, van Schoor, N M & Maggi, S 2016, ' How Hand Osteoarthritis, Comorbidity, and Pain Interact to Determine Functional Limitation in Older People: Observations From the European Project on OSteoArthritis Study ', Arthritis & rheumatology, vol. 68, no. 11, pp. 2662-2670 . https://doi.org/10.1002/art.39757
Arthritis & rheumatology, 68(11), 2662-2670. John Wiley and Sons Ltd
ISSN: 2326-5191
DOI: 10.1002/art.39757
Popis: To examine the role of comorbidity and pain in the associations existing between hand osteoarthritis (OA) and self-reported as well as performance-based physical function in a general elderly population.The data of 2942 participants in the European Project on OSteoArthritis, aged 65 to 85 years, belonging to 6 European cohorts (Germany, Italy, the Netherlands, Spain, Sweden and the United Kingdom) were studied. Outcomes considered self-reported physical functioning subscale scores determined using the Australian/Canadian OA Hand Index (AUSCAN) and a performance-based muscle strength measure, which was quantified using a strain-gauge dynamometer.In the association between hand OA and self-reported as well as performance-based functional limitations, comorbidity was not a confounder and the role of pain as a mediator was instead confirmed. Anxiety, depression, stroke and osteoporosis were associated with more impaired AUSCAN scores. Depression and osteoporosis were associated with less grip strength.Study results have demonstrated that although comorbidity was decidedly and independently associated with hand functional limitation, it has no effect on the hand OA-physical function relationship. Hand OA was found to be associated with self-reported as well as with performance-based physical function impairment; the association was found to be partially mediated by pain, which reduces its impact. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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