Transforming growth factor -α expression in rat experimental hepatocarcinogenesis

Autor:	Pérez-Tomás, R., Mayol, X., Culleré, X., Díaz Ruiz, C., Domingo, J.
Přispěvatelé:	Universitat de Barcelona
Jazyk:	angličtina
Rok vydání:	1992
Předmět:	Tumour promotion Hepatocarcinogenesis Rats as laboratory animals Liver cells Factors de creixement Cèl·lules hepàtiques Càncer de fetge 6 - Ciencias aplicadas::61 - Medicina [CDU] Veterinary histopathology Histopatologia veterinària Growth factors Liver cancer Rates (Animals de laboratori) Tumors
Zdroj:	Recercat. Dipósit de la Recerca de Catalunya instname DIGITUM. Depósito Digital Institucional de la Universidad de Murcia Dipòsit Digital de la UB Universidad de Barcelona
Popis:	Growth factors in general and transforming growth factor-a in particular have been related to cell proliferation and cell differentiation. This study was designed to clarify the distribution pattem of TGF-a in chemically-induced hepatocarcinogenesis. Sprague- Dawley rats were subjected to different non-intensive or intensive carcinogenic treatments using diethylnitrosamine (DEN) as carcinogen and ethinyl estradiol (EE) as promoter. The livers were fixed in 2% paraformaldehyde, dehydrated in a series of ethanol solutions, embedded in paraffin and sectioned. In the preneoplastic lesions no TGF-a immunoreactive cells were identified, but in some hepatic tumours cell immunostained with TGF-a antibody were observed. These results suggest that the cells capable of expressing TGF-a constitutively may be involved in neoplastic development in vivo.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a9d3a4c168bef609f6cefe6a492bf911 http://hdl.handle.net/2445/105882 Zobrazit plný text záznamu