Mononuclear cell infiltrate, HLA-Dr expression and proliferation in 37 acoustic schwannomas
| Autor: | Rossi, M.L., Jones, N.R., Esiri, M.M., Havas, L., Nakamura, N., Coakham, H.B. |
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| Jazyk: | angličtina |
| Rok vydání: | 1990 |
| Předmět: | |
| Zdroj: | DIGITUM. Depósito Digital Institucional de la Universidad de Murcia instname |
| Popis: | Frozen sections from 37 schwannomas of the V111 nerve were reacted with a panel of monoclonal antibodies to macrophage, lymphocyte, I-ILA-Dr invariant chain and nuclear proliferation antigens. A moderate number of rnacrophages was demonstrated in 96% of tumours. CD8- and CD4- lymphocytes were detected in slightly smaller numbers in up to 87% and 23% of tumours respectively. B-lyrnphocytes were present in only 2/32 cases and NK-cells were absent from all 16 cases tested. HLA-Dr antigen was expressed by macrophages in most cases and by tumour cells in 13/24 tumours. These findings may represent evidence for a degree of cellular immune response. Occasional cells featuring nuclear proliferation were detected in 15/27 cases. |
| Databáze: | OpenAIRE |
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