Drying of a pharmaceutical compound in the filter dryer
| Autor: | Katić, Robert |
|---|---|
| Přispěvatelé: | Sander, Aleksandra |
| Jazyk: | chorvatština |
| Rok vydání: | 2018 |
| Předmět: |
Sacubitril Valsartan
thermographic camera filtarski sušionik TECHNICAL SCIENCES. Chemical Engineering. Mechanical Thermal and Separation Processes Ramanova spektroskopija termografska kamera Raman spectroscopy Sakubitril Valsartan Sakubitril Valsartan filtarski sušionik Ramanova spektroskopija termografska kamera filter dryer TEHNIČKE ZNANOSTI. Kemijsko inženjerstvo. Mehanički toplinski i separacijski procesi |
| Popis: | Sušenje je ključan proces u proizvodnji farmaceutskog proizvoda. Do nedavno se sušenje provodilo odvojeno od filtracije no kako tehnologija napreduje tako je i taj proces optimiran i ubrzan. Danas se sušenje i filtracija provode u istom uređaju kojeg nazivamo filtarski sušionik. No kako tehnologija napreduje i dalje, tako i zahtjevi za bržom proizvodnjom i boljom kvalitetom proizvoda rastu. Iz tog razloga traže se rješenja koja bi još dodatno ubrzala proces sušenja odnosno dobivanje proizvoda spremnog za sljedeći korak proizvodnje. U ovom radu su pripremljeni uzorci farmaceutskog proizvoda Sakubitril Valsartana. Nakon što je proizvod sintetiziran u reaktoru, sušen je u filtarskom sušioniku i praćen s tri metode: termogravimetrijska metoda, mjerenje Ramanovom spektroskopijom i snimanje termografskom kamerom. Pomoću tih metoda istraženo je mogu li one pridonijeti boljoj analizi uzorka kako bi proces sušenja bio kraći, a rezultati kvalitetniji. Dobiveni rezultati mjerenja Ramanovom spektroskopijom pokazuju da metoda nije prikladna za praćenje sušenja nakon što vlaga u promatranom proizvodu dosegne vrijednost od 20 %, odnosno ovim mjerenjem ne mogu se detektirati iznosi udjela vlage manji od 20 %. Kod termografske kamere cilj je bio istražiti mogu li termogrami (snimke zračenja snimane termografskom kamerom) s velikom sigurnošću pokazati da je vlaga u materijalu homogeno raspodijeljena po cijeloj masi. Ovom metodom može se utvrditi da je udio vlage po čitavoj masi proizvoda odgovarajući što uvelike olakšava praćenje procesa sušenja. Drying is a key process in production of pharmaceuticals. Until recently, drying was done separately from filtration but as technology is improving, the process is optimized and sped up as well. Nowadays drying and filtration are done in the same device called a filter dryer. Since technology is improving even further, there are more and more requirements for faster production and better quality of the final product. That is why solutions are looked for which would further speed up drying process and obtaining product ready for the next step in production line in the least amount of time. In this work, samples of pharmaceutical Sacubitril Valsartan are prepared. After the product is synthesized in reactor, it is dried in the filtar dryer and monitored using three methods: thermogravimetric method, measuring using Raman spectroscopy and recording using thermographic camera. Those methods were employed to investigate if they can contribute to better sample analysis so that drying process becomes shorter. Collected results of measuring with Raman spectroscopy show that this method is not adequate for monitoring of drying after observed product reach the limit of 20 % of moisture in mass, which means that for all samples that have less than 20 % of moisture in mass, device can not detect any differences. Goal with thermographic camera was to investigate if thermograms (images of radiation detected with thermographic camera) can show with great certainty that the moisture in material is distributed homogeneous. Using this method it can be determined that the moisture content is corresponding acroos whole product mass and that makes the monitoring of drying process much easier. |
| Databáze: | OpenAIRE |
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