Preadmission use of renin-angiotensin blockers and rupture of abdominal aortic aneurysm:A nationwide, population-based study
| Autor: | Wemmelund, Holger, Høgh, Annette, Hundborg, Heidi H, Johnsen, Søren P, Lindholt, Jes S |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Aged
80 and over Male Risk Rupture Aortic Rupture Denmark Research Support Non-U.S. Gov't Pharmacoepidemiology Angiotensin-Converting Enzyme Inhibitors Middle Aged Prognosis Renin-Angiotensin System Angiotensin Receptor Antagonists Patient Admission Case-Control Studies Population Surveillance Journal Article Humans Abdominal aortic aneurysm Female Registries Angiotensin converting enzyme inhibitor Angiotensin receptor blocker Aged Aortic Aneurysm Abdominal |
| Zdroj: | Wemmelund, H, Høgh, A, Hundborg, H H, Johnsen, S P & Lindholt, J S 2016, ' Preadmission use of renin-angiotensin blockers and rupture of abdominal aortic aneurysm : A nationwide, population-based study ', Pharmacoepidemiology and Drug Safety, vol. 25, no. 2, pp. 141-150 . https://doi.org/10.1002/pds.3913 Wemmelund, H, Høgh, A, Hundborg, H H, Johnsen, S P & Lindholt, J S 2016, ' Preadmission use of renin-angiotensin blockers and rupture of abdominal aortic aneurysm : a nationwide, population-based study ', Pharmacoepidemiology and Drug Safety, vol. 25, no. 2, pp. 141-150 . https://doi.org/10.1002/pds.3913 |
| Popis: | PURPOSE: Rupture of abdominal aortic aneurysms (rAAA) is associated with high mortality. Use of angiotensin converting enzyme inhibitors (ACE-inhibitors) and angiotensin receptor blockers (ARBs) has been suggested to reduce the risk of rAAA. This nationwide, combined case-control and follow-up study aims to examine the possible impact of preadmission renin-angiotensin system blockade on the risk of rAAA and case fatality following rAAA.METHODS: Using Danish healthcare registries, a combined case-control and follow-up study was conducted among all patients with a first-time hospital admission for rAAA and AAA controls without rupture in Denmark from 1996 to 2012. Individual-level data were obtained on preadmission drug use, comorbidity, socioeconomic factors, healthcare services use, and death.RESULTS: The adjusted age-matched and sex-matched odds ratios (adj. OR) were 0.96 (95% confidence interval (CI): 0.85; 1.07) for rAAA for current ACE-inhibitor users and 0.93 (95%CI: 0.79; 1.09) for current ARB users compared with never users. Propensity score-matched analyses yielded similar results for current ACE-inhibitor users (adj. OR: 1.02, 95%CI: 0.88; 1.19) and current ARB users (adj. OR: 1.02, 95%CI: 0.83; 1.26). The total 30-day mortality rate after hospital admission was 61.0% in current ACE-inhibitor users compared with 59.4% in non-ACE-inhibitor users (adjusted mortality rate ratio (adj. MRR) 1.06, 95%CI: 0.94; 1.20) and 58.6% in current ARB users compared with 59.9% in non-ARB users (adj. MRR: 0.96, 95%CI: 0.82; 1.14).CONCLUSION: Use of renin-angiotensin system blockade was not associated with a lower risk of rAAA or lower case fatality following rAAA. |
| Databáze: | OpenAIRE |
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