Synthesis and anticancer activity of new pyrrolocarbazoles and pyrrolo-beta-carbolines
| Autor: | M. Boisbrun M. Leonce S. Pfeiffer B. Renard P. Lozach O. Meijer L. Lansiaux A. Bailly C. Sapi J., Laronze, J. Y., Laronze, Meijer, L., Lozach, O. |
|---|---|
| Přispěvatelé: | Molécules et cibles thérapeutiques (MCT), Station biologique de Roscoff [Roscoff] (SBR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Tumor
Non-U.S. Gov't Structure-Activity Relationship Temperature Titrimetry Carbazoles/chemical DNA Footprinting Cell Cycle/drug effects Enzyme Inhibitors/chemical synthesis/chemistry/pharmacology/toxicity Glycogen Synthase Kinase 3/antagonists & inhibitors/metabolism Indoles/chemistry Inhibitory Concentration 50 Mice Molecular Structure Nucleic Acid Denaturation Pyrroles/*chemistry Research Support Carbolines/chemical Antineoplastic Agents/*chemical synthesis/chemistry/*pharmacology/toxicity DNA/genetics/metabolism Cell Line Animals Type I/antagonists & inhibitors/metabolism [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology CDC2 Protein Kinase/antagonists &inhibitors/metabolism synthesis/*chemistry/*pharmacology/toxicity DNA Topoisomerases |
| Zdroj: | Bioorganic and Medicinal Chemistry Bioorganic and Medicinal Chemistry, Elsevier, 2005, 13, pp.2263-83 Bioorganic and Medicinal Chemistry, 2005, 13, pp.2263-83 |
| ISSN: | 0968-0896 1464-3391 |
| Popis: | Bended' 1, 3 or 'linear' 2 pyrrolidino-fused (aza)carbazoles were prepared and screened towards a few cancer-related targets. Whereas 'bended' derivatives 1 and 3 proved to be weakly toxic, several members of the 'linear' family strongly interact with DNA, especially derivative 28a. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect