| Autor: |
Johnson, Paula I, Sutton, Patrice, Atchley, Dylan S, Koustas, Erica, Lam, Juleen, Sen, Saunak, Robinson, Karen A, Axelrad, Daniel A, Woodruff, Tracey J |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Environmental health perspectives, vol 122, iss 10 |
| Popis: |
BackgroundThe Navigation Guide methodology was developed to meet the need for a robust method of systematic and transparent research synthesis in environmental health science. We conducted a case study systematic review to support proof of concept of the method.ObjectiveWe applied the Navigation Guide systematic review methodology to determine whether developmental exposure to perfluorooctanoic acid (PFOA) affects fetal growth in humans.MethodsWe applied the first 3 steps of the Navigation Guide methodology to human epidemiological data: 1) specify the study question, 2) select the evidence, and 3) rate the quality and strength of the evidence. We developed a protocol, conducted a comprehensive search of the literature, and identified relevant studies using prespecified criteria. We evaluated each study for risk of bias and conducted meta-analyses on a subset of studies. We rated quality and strength of the entire body of human evidence.ResultsWe identified 18 human studies that met our inclusion criteria, and 9 of these were combined through meta-analysis. Through meta-analysis, we estimated that a 1-ng/mL increase in serum or plasma PFOA was associated with a -18.9 g (95% CI: -29.8, -7.9) difference in birth weight. We concluded that the risk of bias across studies was low, and we assigned a "moderate" quality rating to the overall body of human evidence.ConclusionOn the basis of this first application of the Navigation Guide systematic review methodology, we concluded that there is "sufficient" human evidence that developmental exposure to PFOA reduces fetal growth. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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