Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease
| Autor: | Yokoyama, Jennifer S, Wang, Yunpeng, Schork, Andrew J, Thompson, Wesley K, Karch, Celeste M, Cruchaga, Carlos, McEvoy, Linda K, Witoelar, Aree, Chen, Chi-Hua, Holland, Dominic, Brewer, James B, Franke, Andre, Dillon, William P, Wilson, David M, Mukherjee, Pratik, Hess, Christopher P, Miller, Zachary, Bonham, Luke W, Shen, Jeffrey, Rabinovici, Gil D, Rosen, Howard J, Miller, Bruce L, Hyman, Bradley T, Schellenberg, Gerard D, Karlsen, Tom H, Andreassen, Ole A, Dale, Anders M, Desikan, Rahul S, Alzheimer’s Disease Neuroimaging Initiative |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Aging Clinical Sciences Neurodegenerative Alzheimer's Disease Autoimmune Disease Alzheimer Disease Clinical Research Acquired Cognitive Impairment Genetics Humans 2.1 Biological and endogenous factors Polymorphism Aetiology Inflammation Neurology & Neurosurgery Prevention Human Genome Inflammatory Bowel Disease Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Alzheimer’s Disease Neuroimaging Initiative Single Nucleotide Brain Disorders HLA-DRB5 Chains Phosphotransferases (Alcohol Group Acceptor) Neurological Female Dementia Cognitive Sciences Cognition Disorders Digestive Diseases Genome-Wide Association Study |
| Zdroj: | JAMA neurology, vol 73, iss 6 |
| Popis: | ImportanceLate-onset Alzheimer disease (AD), the most common form of dementia, places a large burden on families and society. Although epidemiological and clinical evidence suggests a relationship between inflammation and AD, their relationship is not well understood and could have implications for treatment and prevention strategies.ObjectiveTo determine whether a subset of genes involved with increased risk of inflammation are also associated with increased risk for AD.Design, setting, and participantsIn a genetic epidemiology study conducted in July 2015, we systematically investigated genetic overlap between AD (International Genomics of Alzheimer's Project stage 1) and Crohn disease, ulcerative colitis, rheumatoid arthritis, type 1 diabetes, celiac disease, and psoriasis using summary data from genome-wide association studies at multiple academic clinical research centers. P values and odds ratios from genome-wide association studies of more than 100 000 individuals were from previous comparisons of patients vs respective control cohorts. Diagnosis for each disorder was previously established for the parent study using consensus criteria.Main outcomes and measuresThe primary outcome was the pleiotropic (conjunction) false discovery rate P value. Follow-up for candidate variants included neuritic plaque and neurofibrillary tangle pathology; longitudinal Alzheimer's Disease Assessment Scale cognitive subscale scores as a measure of cognitive dysfunction (Alzheimer's Disease Neuroimaging Initiative); and gene expression in AD vs control brains (Gene Expression Omnibus data).ResultsEight single-nucleotide polymorphisms (false discovery rate P |
| Databáze: | OpenAIRE |
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