Observation of metal nanoparticles at atomic resolution in Pt-based cancer chemotherapeutics
| Autor: | Sheader, AA, Varambhia, AM, Fleck, RA, Flatters, SJL, Nellist, PD |
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| Rok vydání: | 2018 |
| Zdroj: | Sheader, A A, Varambhia, A M, Fleck, R A, Flatters, S J L & Nellist, P D 2018, ' Observation of metal nanoparticles at atomic resolution in Pt-based cancer chemotherapeutics ', Journal of Microscopy, vol. 270, no. 1, pp. 92-97 . https://doi.org/10.1111/jmi.12659 |
| DOI: | 10.1111/jmi.12659 |
| Popis: | The chemotherapeutics cisplatin and oxaliplatin are importanttools in the fight against cancer. Both compounds areplatinum complexes. Aberration-corrected scanning transmissionelectron microscopy using the annular dark-fieldimaging mode now routinely provides single-atom sensitivitywith atomic number contrast. Here, this imaging mode is usedto directly image the platinum within the two drugs in theirdried form on an amorphous carbon support film. The oxaliplatinis found to have wetted the supporting amorphous carbon,forming disordered clusters suggesting that the platinumhas remained within the complex. Conversely, the cisplatinsample reveals 1.8-nm-diameter metallic platinum clusters.The size and shape of the clusters do not appear to be dependenton drying rate nor formed by beam damage, which maysuggest that they were present in the original drug solution. |
| Databáze: | OpenAIRE |
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