Absence of HBV and HCV, HTLV-I and -II, and human herpes virus-8 activation after allogeneic RBC transfusion in patients with advanced HIV-1 infection

Autor: Asmuth, David M, Kalish, Leslie A, Laycock, Megan E, Murphy, Edward L, Mohr, Beth A, Lee, Tzong-Hae, Gallarda, James, Giachetti, Cristina, Dollard, Sheila C, van der Horst, Charles M, Grant, Robert M, Busch, Michael P, Viral Activation Transfusion Study Group
Rok vydání: 2003
Předmět:
Hepatitis B virus
viruses
Chronic Liver Disease and Cirrhosis
Clinical Trials and Supportive Activities
Clinical Sciences
Immunology
Hepacivirus
Cardiorespiratory Medicine and Haematology
2.2 Factors relating to physical environment
Antibodies
Hepatitis
Hepatitis - B
Double-Blind Method
Hepatitis - C
Clinical Research
Humans
2.2 Factors relating to the physical environment
2.1 Biological and endogenous factors
Viral Activation Transfusion Study Group
Viral
Prospective Studies
Herpesvirus 8
Aetiology
Human T-lymphotropic virus 1
Acquired Immunodeficiency Syndrome
Liver Disease
Human T-lymphotropic virus 2
virus diseases
Evaluation of treatments and therapeutic interventions
DNA
Viral Load
Emerging Infectious Diseases
Infectious Diseases
Good Health and Well Being
Cardiovascular System & Hematology
6.1 Pharmaceuticals
HIV/AIDS
Virus Activation
Erythrocyte Transfusion
Digestive Diseases
Infection
Human
Zdroj: Transfusion, vol 43, iss 4
Popis: BACKGROUND:The Viral Activation Transfusion Study was a prospective, randomized, double-blind comparison of transfusion with WBC-reduced versus non-WBC-reduced RBCs to HIV+ patients. The primary study characterized the effect of transfusion on HIV and CMV activation by monitoring viral load changes. The present study analyzed HBV, HCV, HTLV-I and -II, and human herpes virus-8 (HHV-8) viral load before and after transfusion to evaluate the further hypothesis that global immune stimulation following allogeneic RBC transfusion results in activation and increased viral proliferation of chronic viral infections other than HIV and CMV. STUDY DESIGN AND METHODS:Baseline samples from 519 to 523 subjects were screened for HBV, HCV, HTLV-I and -II, and HHV-8 infection, and baseline, serial weekly, and quarterly blood samples from infected subjects in the non-WBC-reduced arm were evaluated for changes from baseline in viral nucleic acid and ALT levels. RESULTS:Seroprevalence of HBV, HCV, HTLV-I and -II, and HHV-8 was 68, 25, 5, and 30 percent, respectively. No significant induction of HBV, HCV, HHV-8, or HTLV-I and -II viral replication following allogeneic transfusion of non-WBC-reduced blood was observed. A significant, albeit small, association was observed between transfusion and ALT. CONCLUSIONS:Based on these results and our previous finding that no adverse effect on HIV and CMV viral load and disease progression results from allogeneic transfusion, no evidence is found to support the selective use of WBC-reduced blood components for HIV-infected patients.
Databáze: OpenAIRE
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