Absence of HBV and HCV, HTLV-I and -II, and human herpes virus-8 activation after allogeneic RBC transfusion in patients with advanced HIV-1 infection
Autor: | Asmuth, David M, Kalish, Leslie A, Laycock, Megan E, Murphy, Edward L, Mohr, Beth A, Lee, Tzong-Hae, Gallarda, James, Giachetti, Cristina, Dollard, Sheila C, van der Horst, Charles M, Grant, Robert M, Busch, Michael P, Viral Activation Transfusion Study Group |
---|---|
Rok vydání: | 2003 |
Předmět: |
Hepatitis B virus
viruses Chronic Liver Disease and Cirrhosis Clinical Trials and Supportive Activities Clinical Sciences Immunology Hepacivirus Cardiorespiratory Medicine and Haematology 2.2 Factors relating to physical environment Antibodies Hepatitis Hepatitis - B Double-Blind Method Hepatitis - C Clinical Research Humans 2.2 Factors relating to the physical environment 2.1 Biological and endogenous factors Viral Activation Transfusion Study Group Viral Prospective Studies Herpesvirus 8 Aetiology Human T-lymphotropic virus 1 Acquired Immunodeficiency Syndrome Liver Disease Human T-lymphotropic virus 2 virus diseases Evaluation of treatments and therapeutic interventions DNA Viral Load Emerging Infectious Diseases Infectious Diseases Good Health and Well Being Cardiovascular System & Hematology 6.1 Pharmaceuticals HIV/AIDS Virus Activation Erythrocyte Transfusion Digestive Diseases Infection Human |
Zdroj: | Transfusion, vol 43, iss 4 |
Popis: | BACKGROUND:The Viral Activation Transfusion Study was a prospective, randomized, double-blind comparison of transfusion with WBC-reduced versus non-WBC-reduced RBCs to HIV+ patients. The primary study characterized the effect of transfusion on HIV and CMV activation by monitoring viral load changes. The present study analyzed HBV, HCV, HTLV-I and -II, and human herpes virus-8 (HHV-8) viral load before and after transfusion to evaluate the further hypothesis that global immune stimulation following allogeneic RBC transfusion results in activation and increased viral proliferation of chronic viral infections other than HIV and CMV. STUDY DESIGN AND METHODS:Baseline samples from 519 to 523 subjects were screened for HBV, HCV, HTLV-I and -II, and HHV-8 infection, and baseline, serial weekly, and quarterly blood samples from infected subjects in the non-WBC-reduced arm were evaluated for changes from baseline in viral nucleic acid and ALT levels. RESULTS:Seroprevalence of HBV, HCV, HTLV-I and -II, and HHV-8 was 68, 25, 5, and 30 percent, respectively. No significant induction of HBV, HCV, HHV-8, or HTLV-I and -II viral replication following allogeneic transfusion of non-WBC-reduced blood was observed. A significant, albeit small, association was observed between transfusion and ALT. CONCLUSIONS:Based on these results and our previous finding that no adverse effect on HIV and CMV viral load and disease progression results from allogeneic transfusion, no evidence is found to support the selective use of WBC-reduced blood components for HIV-infected patients. |
Databáze: | OpenAIRE |
Externí odkaz: |
načítá se...