Diagnosis and management of pain in Parkinson's disease : an original approach

Autor: Mylius, Veit, Carsten Möller, Jens, Bohlhalter, Stephan, Ciampi de Andrade, Daniel, Pérez Lloret, Santiago
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Drugs & Aging. 2021, 38. doi:10.1007/s40266-021-00867-1
Repositorio Institucional (UCA)
Pontificia Universidad Católica Argentina
instacron:UCA
DOI: 10.1007/s40266-021-00867-1
Popis: Fil: Mylius, Veit. Center for Neurorehabilitation. Department of Neurology; Suiza Fil: Mylius, Veit. Philipps University. Department of Neurology; Alemania Fil: Mylius, Veit. Kantonsspital St. Gallen. Department of Neurology; Suiza Fil: Carsten Möller, Jens. Philipps University. Department of Neurology; Alemania Fil: Carsten Möller, Jens. Parkinson Center. Center for Neurological Rehabilitation; Suiza Fil: Bohlhalter, Stephan. Luzerner Kantonsspital. Neurocenter; Suiza Fil:Bohlhalter, Stephan. University of Zurich. Dept. of Neurology; Suiza Fil: Ciampi de Andrade, Daniel. Universidade de Sao Paulo. Faculdade de Medicina. Departamento de Neurologia. Centro de Dor; Brasil Fil: Ciampi de Andrade, Daniel. Instituto do Cancer de Sao Paulo Octavio Frias de Oliveira; Brasil Fil: Ciampi de Andrade, Daniel. Universidade de Sao Paulo. Hospital das Clinicas; Brasil Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Pérez Lloret, Santiago. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina Abstract: Pain is a frequent and disabling non-motor feature of Parkinson’s disease (PD). The recently proposed PD Pain Classification System (PD-PCS) allows to determine an association of pain with PD before allocating to the main pain mechanism (i.e. nociceptive, neuropathic, and nociplastic). In this article, previous studies on treatments for pain in PD are summarized according to the pain mechanisms. A mechanistic approach to treatment is discussed. We suggest that the first step should be optimizing dopaminergic therapy before other therapy is started. When these treatments remain unsuccessful, further causes of pain must be considered. The role of drugs, invasive treatments, and physiotherapeutic interventions are discussed with a focus on older PD patients considering polypharmacy, altered pharmacokinetics, and comorbidities.
Databáze: OpenAIRE
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