Effector T(H)17 Cells Give Rise to Long-Lived T-RM Cells that Are Essential for an Immediate Response against Bacterial Infection
| Autor: | Amezcua Vesely MC, Pallis P, Bielecki P, Low JS, Zhao J, Harman CCD, Kroehling L, Jackson R, Bailis W, Licona-Limón P, Xu H, Iijima N, Pillai PS, Kaplan DH, Weaver CT, Kluger Y, Kowalczyk MS, Iwasaki A, Pereira JP, Esplugues E, Gagliani N, Flavell RA |
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| Rok vydání: | 2019 |
| Zdroj: | CELL r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) Centro de Investigación Principe Felipe (CIPF) r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) instname |
| ISSN: | 0092-8674 |
| Popis: | Adaptive immunity provides life-long protection by generating central and effector memory T cells and the most recently described tissue resident memory T (T-RM) cells. However, the cellular origin of CD4 T-RM cells and their contribution to host defense remain elusive. Using IL-17A tracking-fate mouse models, we found that a significant fraction of lung CD4 T-RM cells derive from IL-17A-producing effector (T(H)17) cells following immunization with heat-killed Klebsiella pneumonia (Kp). These exT(H)17 T-RM cells are maintained in the lung by IL-7, produced by lymphatic endothelial cells. During a memory response, neither antibodies, gamma delta T cells, nor circulatory T cells are sufficient for the rapid host defense required to eliminate Kp. Conversely, using parabiosis and depletion studies, we demonstrated that exT(H)17 T-RM cells play an important role in bacterial clearance. Thus, we delineate the origin and function of airway CD4 T-RM cells during bacterial infection, offering novel strategies for targeted vaccine design. |
| Databáze: | OpenAIRE |
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