| Autor: |
Bruder-Nascimento, Thiago, Callera, Glaucia, Montezano, Augusto, Antunes, Tayze T., He, Ying, Nguyen Dinh Cat, Aurelie, Ferreira, Nathanne S., Barreto, Pedro A., Olivon, Vânia C., Tostes, Rita C., Touyz, Rhian |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 11, Iss 9, p e0162731 (2016) |
| ISSN: |
1932-6203 |
| Popis: |
Potential benefits of statins in the treatment of chronic kidney disease beyond lipid-lowering effects have been described. However, molecular mechanisms involved in renoprotective actions of statins have not been fully elucidated. We questioned whether statins influence development of diabetic nephropathy through reactive oxygen species, RhoA and Akt/GSK3 pathway, known to be important in renal pathology. Diabetic mice (db/db) and their control counterparts (db/+) were treated with atorvastatin (10 mg/Kg/day, p.o., for 2 weeks). Diabetes-associated renal injury was characterized by albuminuria (albumin:creatinine ratio, db/+: 3.2 ± 0.6 vs. db/db: 12.5 ± 3.1*; *P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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