Effects of sow antibiotic treatment and offspring diet on microbiota and gut barrier throughout life

Autor: Lalles, Jean Paul, Arnal, Marie-Edith, Boudry, Gaëlle, Ferret-Bernard, Stéphanie, Le Huërou-Luron, Isabelle, Zhang, Jing, Smidt, Hauke
Přispěvatelé: ProdInra, Archive Ouverte, Département Alimentation Humaine INRA (ALIM-H), Institut National de la Recherche Agronomique (INRA)-PRES Université Nantes Angers Le Mans (UNAM), Alimentation Adaptations Digestives, Nerveuse et Comportementales (ADNC), Institut National de la Recherche Agronomique (INRA), Wageningen University and Research [Wageningen] (WUR), UAR 1189 Département Alimentation Humaine, Institut National de la Recherche Agronomique (INRA)-Alimentation Humaine (ALIM.H), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Département Alimentation Humaine (DPT ALIM. H), centre de rennes-Institut National de la Recherche Agronomique (INRA), Wageningen University and Research Center (WUR), Institut National de la Recherche Agronomique (INRA)-centre de rennes
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: 64. Annual Meeting of the European Federation of Animal Science (EAAP)
64. Annual Meeting of the European Federation of Animal Science (EAAP), Aug 2013, Nantes, France. Wageningen Academic Publishers, Annual Meeting of the European Association for Animal Production, 19, 2013, Annual Meeting of the European Association for Animal Production
64. Annual Meeting of the European Federation of Animal Science (EAAP), Aug 2013, Nantes, France. Wageningen Academic Publishers, 19, 2013, Annual Meeting of the European Association for Animal Production
Book of abstracts of the 64th annual meeting of the european federation of animal science. (19)2013; 64. Annual Meeting of the European Federation of Animal Science (EAAP), Nantes, FRA, 2013-08-26-2013-08-29, 550
Popis: Neonatal microbial colonization of the gut participates in anatomical and functional development of this organ. Perinatal use of antibiotics (AB) is suspected to contribute to later development of diet-related diseases in human, through early alterations in microbial colonization impacting gut and distant-organ function. In that respect, gut barrier function, including permeability, detoxification, immune and cytoprotection systems are important aspects. AB treatment around farrowing also happens in pig production. However, the consequences on gut barrier throughout life in offspring are unknown. During the Interplay EU project, we developed a pig model of AB-induced early microbiota disturbances for investigating short- and longerterm consequences on offspring gut barrier function. Sows were given orally a broad spectrum AB around farrowing (day -10 to +21). Offspring were sacrificed during suckling, after weaning and at 6 months of age. In the long-term protocol, offspring were fed a high fat (vs. low fat) diet for 4 weeks as a model of diet-induced low grade inflammation. AB treatment of sows affected their faecal microbiota and that of their offspring. We observed age-dependent alterations in offspring ileal and colonic permeability, ileal epithelial transcriptome, mucosal inflammation traits, digestive enzymes, ileal and colonic protective heat shock proteins and in digesta concentrations of pro-inflammatory bacterial components. Interactions between perinatal antibiotic treatment of mothers and offspring adult diet was often significant for gut parameters. Data indicate that both early gut microbial colonization disturbances and late nutritional environment condition gut function in adulthood according to specific spatio-temporal patterns. Underlying molecular mechanisms and correlations between physiological and microbial traits are under investigation.
Databáze: OpenAIRE
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