Magnetic resonance perfusion image features uncover an angiogenic subgroup of glioblastoma patients with poor survival and better response to antiangiogenic treatment
| Autor: | Liu, Tiffany T, Achrol, Achal S, Mitchell, Lex A, Rodriguez, Scott A, Feroze, Abdullah, Iv, Michael, Kim, Christine, Chaudhary, Navjot, Gevaert, Olivier, Stuart, Josh M, Harsh, Griffith R, Chang, Steven D, Rubin, Daniel L |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Genotype Clinical Trials and Supportive Activities Oncology and Carcinogenesis Angiogenesis Inhibitors Kaplan-Meier Estimate and over Cohort Studies Young Adult angiogenesis quantitative perfusion-weighted imaging Rare Diseases Clinical Research radiogenomic analysis 80 and over Humans Cluster Analysis Oncology & Carcinogenesis Neovascularization Aged Cancer Pathologic Brain Neoplasms Neurosciences Middle Aged patient stratification Brain Disorders Brain Cancer Treatment Outcome antiangiogenic therapy Biomedical Imaging Female Glioblastoma Magnetic Resonance Angiography Biotechnology |
| Zdroj: | Liu, TT; Achrol, AS; Mitchell, LA; Rodriguez, SA; Feroze, A; Iv, M; et al.(2017). Magnetic resonance perfusion image features uncover an angiogenic subgroup of glioblastoma patients with poor survival and better response to antiangiogenic treatment. Neuro-Oncology, 19(7), 997-1007. doi: 10.1093/neuonc/now270. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/0k60p5k2 Neuro-oncology, vol 19, iss 7 |
| DOI: | 10.1093/neuonc/now270. |
| Popis: | © The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. Background. In previous clinical trials, antiangiogenic therapies such as bevacizumab did not show efficacy in patients with newly diagnosed glioblastoma (GBM). This may be a result of the heterogeneity of GBM, which has a variety of imaging-based phenotypes and gene expression patterns. In this study, we sought to identify a phenotypic subtype of GBM patients who have distinct tumor-image features and molecular activities and who may benefit from antiangiogenic therapies. Methods. Quantitative image features characterizing subregions of tumors and the whole tumor were extracted from preoperative and pretherapy perfusion magnetic resonance (MR) images of 117 GBM patients in 2 independent cohorts. Unsupervised consensus clustering was performed to identify robust clusters of GBM in each cohort. Cox survival and gene set enrichment analyses were conducted to characterize the clinical significance and molecular pathway activities of the clusters. The differential treatment efficacy of antiangiogenic therapy between the clusters was evaluated. Results. A subgroup of patients with elevated perfusion features was identified and was significantly associated with poor patient survival after accounting for other clinical covariates (P values 3) consistently found in both cohorts. Angiogenesis and hypoxia pathways were enriched in this subgroup of patients, suggesting the potential efficacy of antiangiogenic therapy. Patients of the angiogenic subgroups pooled from both cohorts, who had chemotherapy information available, had significantly longer survival when treated with antiangiogenic therapy (log-rank P=.022). Conclusions. Our findings suggest that an angiogenic subtype of GBM patients may benefit from antiangiogenic therapy with improved overall survival. |
| Databáze: | OpenAIRE |
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