131Ba as a promising SPECT-diagnostic match for 223/224Radium
| Autor: | Reissig, F., Bauer, D., Ullrich, M., Kreller, M., Pietzsch, J., Kopka, K., Pietzsch, H.-J., Walther, M., Mamat, C. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | eSRS 2021 Virtual Meeting, 17.-19.05.2021, Nantes, France Nuclear Medicine and Biology 96-97/S1(2021), S107 |
| Popis: | We recognize 131Ba as a SPECT radionuclide, which provides a diagnostic match for the therapeutic alpha-emitting radionuclides 223Ra and 224Ra. The gamma-emitter barium-131 (t½ = 11.5 d) decays with an energy of 123.8 keV (30% intensity) of the first decay via cesium-131 (t½ = 9.7 d) to stable xenon-131, each by electron capture. Our aim was to develop of a straightforward resin-based radiochemical separation to yield 131Ba with high radionuclide purity. Furthermore, the radiolabeling of the complexing agent macropa with [131Ba]Ba2+ using mild labeling conditions was intended. For this purpose, different TLC systems as reaction control were utilized. The radiopharma-cological characterization of 131Ba-labeled macropa in comparison to uncomplexed [131Ba]Ba2+ was carried out in healthy mice, including biodistribution and small animal SPECT/CT experiments. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|