Temporal changes in the composition of a large multicenter kidney exchange clearinghouse: Do the hard-to-match accumulate?
| Autor: | Holscher, Courtenay M, Jackson, Kyle, Thomas, Alvin G, Haugen, Christine E, DiBrito, Sandra R, Covarrubias, Karina, Gentry, Sommer E, Ronin, Matthew, Waterman, Amy D, Massie, Allan B, Garonzik Wang, Jacqueline, Segev, Dorry L |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Tissue and Organ Procurement Histocompatibility Testing kidney transplantation/nephrology Middle Aged paired exchange [donors and donation] Prognosis health services and outcomes research Kidney Transplantation Medical and Health Sciences Tissue Donors sensitization Donor Selection Blood Grouping and Crossmatching Humans Multicenter Studies as Topic Female Surgery living donor [kidney transplantation] Registries living [donors and donation] Follow-Up Studies |
| Zdroj: | Holscher, CM; Jackson, K; Thomas, AG; Haugen, CE; DiBrito, SR; Covarrubias, K; et al.(2018). Temporal changes in the composition of a large multicenter kidney exchange clearinghouse: Do the hard-to-match accumulate?. AMERICAN JOURNAL OF TRANSPLANTATION, 18(11), 2791-2797. doi: 10.1111/ajt.15046. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4r232799 American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol 18, iss 11 |
| DOI: | 10.1111/ajt.15046. |
| Popis: | One criticism of kidney paired donation (KPD) is that easy-to-match candidates leave the registry quickly, thus concentrating the pool with hard-to-match sensitized and blood type O candidates. We studied candidate/donor pairs who registered with the National Kidney Registry (NKR), the largest US KPD clearinghouse, from January 2012-June 2016. There were no changes in age, gender, BMI, race, ABO blood type, or panel-reactive antibody (PRA) of newly registering candidates over time, with consistent registration of hard-to-match candidates (59% type O and 38% PRA ≥97%). However, there was no accumulation of type O candidates over time, presumably due to increasing numbers of nondirected type O donors. Although there was an initial accumulation of candidates with PRA ≥97% (from 33% of the pool in 2012% to 43% in 2014, P = .03), the proportion decreased to 17% by June 2016 (P |
| Databáze: | OpenAIRE |
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