| Autor: |
Paling, Fleur P, Wolkewitz, Martin, Bode, Lonneke G M, Klein Klouwenberg, Peter M C, Ong, David S Y, Depuydt, Pieter, de Bus, Liesbet, Sifakis, Frangiscos, Bonten, Marc J M, Kluijtmans, Jan |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Clinical Microbiology and Infection, 23(1). Elsevier Limited |
| ISSN: |
1198-743X |
| Popis: |
OBJECTIVE: To quantify the incidence of intensive care unit (ICU) acquired pneumonia caused by Staphylococcus aureus (S. aureus) and its association with S. aureus colonization at ICU admission. METHODS: This was a post-hoc analysis of two cohort studies in critically ill patients. The primary outcome was the incidence of microbiologically confirmed S. aureus ICU-acquired pneumonia. Incidences of S. aureus ICU pneumonia and associations with S. aureus colonization at ICU admission were determined using competing risks analyses. In all ICUs, patients were screened for respiratory tract S. aureus carriage on admission as part of infection control policies. Pooling of data was deemed not possible due to heterogeneity in baseline differences in patient population. RESULTS: The two cohort studies contained data of 9,156 ICU patients. The average carriage rate of S. aureus among screened patients was 12.7%. In total, 1,185 (12.9%) patients developed ICU pneumonia. Incidences of S. aureus ICU pneumonia were 1.33% and 1.08% in cohorts 1 and 2, respectively. After accounting for competing events, the adjusted subdistribution hazard ratio (SHR) of S. aureus colonization at admission for developing S. aureus ICU pneumonia was 9.55, (95% confidence interval [CI] 5.31-17.18) in cohort 1 and 14.54 (95% CI 7.24-29.21) in cohort 2. CONCLUSION: The overall cumulative incidence of S. aureus ICU pneumonia in these ICUs was low. Patients colonized with S. aureus at ICU admission had an up to 15 times increased risk for developing this outcome compared to non-colonized patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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