The connection of the tear function of the patients with Amiodarone keratopathy
| Autor: | Mukuno, Hirokazu, Katakami, Chikako |
|---|---|
| Jazyk: | japonština |
| Rok vydání: | 2005 |
| Předmět: | |
| Zdroj: | 神戸大学医学部紀要. 65(1/2/3/4):19-23 |
| ISSN: | 0075-6431 |
| Popis: | 目的:アミオダロン角膜症の発症原因のひとつとして,アミオダロンの涙腺脂肪組織への沈着がいわれている。そこで今回,角膜症の進行と涙液動態との関連について検討したので報告する。方法:アミオダロン投与患者のうち使用開始後3週間以上眼科的に観察可能であった12名(男性9名,女性3名)24眼に対しOrlando分類を用いた角膜症の進行程度と,シルマー試験(第1法),涙液層破壊時間,涙液油層検査による涙液動態との関連について検討した。結果:角膜症発症までの期間および角膜症の重症度と各涙液検査の間に明らかな相関関係は認められなかったが,19眼(79.2%)で涙液層破壊時間が5.0秒以下またはシルマー値5.0mm以下,20眼(83.3%)で涙液油層検査がGradeIII以上を示した。結論:アミオダロン角膜症患者はドライアイの傾向が強い事が示された。 Purpose: Amiodarone keratopayhy is thorgt to be caused by the deposition of Amiodarone to a lacrimal gland. In the present study, we examined the connection of the tear finction of the patients with Amiodarone keratopathy. Method: Twenty-four eyes of 12 patients (9 male, and 3 female). whose follow-up period was longer than 3 weeks after the use of Amiodarone were recruited to this study. Amiodarone keratopathy was graded using Orlando classification. Schirmer test, BUT measurement and tear film lipid layer interferometry (DR-1) were performed as tear function tests. Result: The period of the onset of keratopathy, and the stage of orlando classification were not obviously correlated with each tear function test. Howerver 20 eyes (83.3%) showed Grade III and higher in DR-1, 19 eyes (79.2%) showed less than 5 sec in BUT or less than 5.0mm in Schirmer test value. There is no obvious correlation between, and each tears examination, but in 20 eyes (83.3%) DR-1 showed more than Grade III, and in a 19 eyes (79.2%) BUT showed less than 5.0 second nor Schirmer value less than 5.0mm. Conclusion: Patients with Amiodarone keratopathy showed high tendency of dry eye. |
| Databáze: | OpenAIRE |
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