Study of the Effect of Linoleic Acid on the Expression Level of MicroRNA-106b and MicroRNA-20a and their Related Target MHC Class I Chain-related Protein A in Docetaxel-treated Gastric Cancer Cells
| Autor: | Shekari, Najibeh, Kazemi, Tohid, Moradi, Maedeh, Eghbali, Elham, Sepehri, Bita, Shahgoli, Vahid Khaze, Shirmohamadi, Masoud |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Middle East Journal of Cancer, Vol 12, Iss 3, Pp 342-349 (2021) Shekari, N, Kazemi, T, Moradi, M, Eghbali, E, Sepehri, B, Shahgoli, V K & Shirmohamadi, M 2021, ' Study of the effect of linoleic acid on the expression level of MicroRNA-106b and MicroRNA-20a and their related target MHC class I chain-related protein a in docetaxel-treated gastric cancer cells ', Middle East Journal of Cancer, vol. 12, no. 3, pp. 342-349 . https://doi.org/10.30476/mejc.2021.87303.1406 |
| ISSN: | 2008-6687 2008-6709 |
| DOI: | 10.30476/mejc.2021.87303.1406 |
| Popis: | Background: MicroRNAs are involved in response to therapeutic agents and have the ability to regulate the expression level of the targets associated with cancer growth and progression. As a dangerous signal in tumor cells, increased expression level of MHC class I chain-related protein A (MICA) could activate the immune system and induce responses to tumor cells. We conducted the present research to study the effect of linoleic acid (LA) and docetaxel alone or in combination with miR-106b, miR-20a, and MICA expression level in metastatic gastric cancer (GC) cell line MKN-45. Method: The study was an in vitro study using the gastric cancer cell line MKN-45, which was cultured and treated with docetaxel and LA. Subsequently, the expression level of miR-106b, miR-20a, and MICA were assessed with quantitative real-time polymerase chain reaction. Results: MiR-106b decreased in LA and LA/docetaxel (P |
| Databáze: | OpenAIRE |
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