| Autor: |
Kulkarni T, Slaughter G, Ego-Osuala C, Kochunov P, Raul Bastarrachea, Mattern V, Andrade M, Pb, Higgins, Ag, Comuzzie, Vs, Voruganti |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Europe PubMed Central |
| Popis: |
Background: Blood glucose levels regulate the rate of insulin secretion, which is the body’s mechanism for preventing excessive elevationin blood glucose. Impaired glucose metabolism and insulin resistance have been linked to excess body fat composition. Here, we quantifyabdominal muscle and abdominal adipose tissue compartments in a large nonhuman primate, the baboon, and investigate their relationshipwith serum glucose response to a hyperglycemic challenge. Methods: Five female baboons were fasted for 16 hours prior to 90 minute body imaging experiment that consisted of a 20-min baseline,followed by a bolus infusion of glucose (500mg/kg). The blood glucose was sampled at regular intervals. The total volumes of the muscle,visceral and subcutaneous adipose tissue were measured. Results and discussion: We found that adipose tissue composition predicted fluctuations in glucose responses to a hyperglycemic challengeof a non-human primate. Animals with higher visceral adiposity showed significantly reduced glucose elimination. The glucose responseswere positively correlated with body weight, visceral and muscle fat (p < 0.005). Polynomial regression analysis showed that bodyweight, visceral and muscle were significant predictors of serum glucose responses (p < 0.001). Conclusions:These results reveal the similarity between humans and baboons with respect to glucose metabolism and strengthen the utility of baboon for biomedical research. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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