| Autor: |
Buchanan, Helena S., Pauff, Steven M., Kosmidis, Tilemachos D., Taladriz-Sender, Andrea, Rutherford, Olivia I., Hatit, Marine Z. C., Fenner, Sabine, Watson, Allan J. B., Burley, Glenn A. |
| Přispěvatelé: |
University of St Andrews. School of Chemistry |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| ISSN: |
1523-7060 |
| Popis: |
This work was supported by an EPSRC-GSK industrial CASE studentship for H.B., a University studentship for T.D.K., and postdoctoral funding for S.P. by the Leverhulme Trust (RPG-2014-313). Two Pd-catalyzed methods to access 6-heteroaryl 2-aminopurine ribonucleosides from 6-chloroguanosine are described. First, Pd-132-catalyzed Suzuki–Miyaura cross-coupling using a series of boron substrates and 6-chloroguanosine forms 6-heteroaryl-2-aminopurines in a single step. The versatility of 6-chloroguanosine is further demonstrated using a modified Sonogashira coupling employing potassium iodide as an additive. Finally, the utility of the 6-alkynyl-2-aminopurine ribonucleoside as a dipolarophile in [3 + 2] cycloadditions is presented, affording triazoles and isoxazoles when reacted with azide and isonitrile 1,3-dipoles, respectively. Publisher PDF |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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