Le variant de l'Adiponutrine I148M est un facteur de risque de cancer du foie associé au VHC chez les patients nord-africains

Autor: Ezzikouri, Sayeh, Alaoui, Rhimou, Tazi, Sana, Nadir, Salwa, Elmdaghri, Naima, Pineau, Pascal, Benjelloun, Soumaya
Přispěvatelé: Laboratoire des Hépatites Virales [Casablanca, Maroc] (LHV), Institut Pasteur du Maroc, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), CHU Ibn Rochd [Casablanca], Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by The European Commission under the Health Cooperation Work Program of the 7th Framework Program for the Research and Technological Development, HepaCute Project (Grant Agreement No. 260844)., European Project: 260844,EC:FP7:HEALTH,FP7-HEALTH-2010-single-stage,HEPACUTE(2010), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Jazyk: angličtina
Rok vydání: 2014
Předmět:
MESH: Carcinoma
Hepatocellular / epidemiology
Hepatocellular carcinoma
MESH: Liver Neoplasms / virology
[SDV.CAN]Life Sciences [q-bio]/Cancer
MESH: Membrane Proteins / genetics
MESH: Genotype
MESH: Morocco / epidemiology
MESH: Risk Factors
MESH: Lipase / genetics
MESH: Liver Neoplasms / genetics
MESH: Gene Frequency
Genetic marker
PNPLA3
MESH: Aged
MESH: Liver Cirrhosis / complications
MESH: Middle Aged
MESH: Humans
MESH: Polymorphism
Single Nucleotide
MESH: Carcinoma
Hepatocellular / genetics
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
MESH: Liver Cirrhosis / virology
MESH: Male
MESH: Carcinoma
Hepatocellular / virology
Spontaneous clearance
[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics
MESH: Liver Neoplasms / epidemiology
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
MESH: Hepadnaviridae / physiology
MESH: Liver Cirrhosis / genetics
MESH: Female
Zdroj: Infection, Genetics and Evolution
Infection, Genetics and Evolution, Elsevier, 2014, 21, pp.179-183. ⟨10.1016/j.meegid.2013.11.005⟩
Infection, Genetics and Evolution, 2014, 21, pp.179-183. ⟨10.1016/j.meegid.2013.11.005⟩
ISSN: 1567-1348
1567-7257
DOI: 10.1016/j.meegid.2013.11.005⟩
Popis: International audience; Recent reports revealed an association between variation in the PNPLA3 gene and alcohol-induced hepatocellular carcinoma among Europeans. We have assessed whether the PNPLA3 rs738409 (I148M) polymorphism may also affect the resolution and/or the progression of hepatitis C in a Moroccan cohort. Genotype and allele frequencies at rs738409 were determined using a TaqMan 5' allelic discrimination assay in 437 individuals. Among them, 230 patients had a persistent infection with hepatitis C virus (HCV) with 129 patients affected by a chronic hepatitis and 101 patients by a hepatocellular carcinoma (HCC). In addition, we analyzed 75 individuals who naturally cleared HCV and 132 healthy subjects. Variation at rs738409 was not associated with significant changes in resolution rate of hepatitis C. By contrast, M/M genotype, present at higher frequencies (22.8%) in HCC patients than in patients with chronic hepatitis C (8.5%, P = 0.004) or control individuals (9.1%, P = 0.005) was associated with a 3-fold increase of liver cancer risk. In North African subjects, the PNPLA3 I148M variant apparently stimulates liver cancer development without interfering on the HCV clearance process. This polymorphism may, therefore, represent a valuable genetic marker to monitor liver cancer risk in populations from the Southern bank of the Mediterranean.
Databáze: OpenAIRE
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