Subthreshold Psychosis in 22q11.2 Deletion Syndrome: Multisite Naturalistic Study
| Autor: | Weisman, Omri, Guri, Yael, Gur, Raquel E, McDonald-McGinn, Donna M, Calkins, Monica E, Tang, Sunny X, Emanuel, Beverly, Zackai, Elaine H, Eliez, Stephan, Schneider, Maude, Schaer, Marie, Kates, Wendy R, Antshel, Kevin M, Fremont, Wanda, Shashi, Vandana, Hooper, Stephen R, Armando, Marco, Vicari, Stefano, Pontillo, Maria, Kushan, Leila, Jalbrzikowski, Maria, Bearden, Carrie E, Cubells, Joseph F, Ousley, Opal Y, Walker, Elaine F, Simon, Tony J, Stoddard, Joel, Niendam, Tara A, van den Bree, Marianne BM, Gothelf, Doron, International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Adolescent International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome Clinical Trials and Supportive Activities Prodromal Symptoms attention deficit/hyperactivity disorder Comorbidity Medical and Health Sciences Young Adult global assessment of functioning velocardiofacial syndrome Clinical Research structured interview for prodromal syndromes Behavioral and Social Science DiGeorge Syndrome Humans anxiety disorder Cognitive Dysfunction Child Pediatric Psychiatry Psychology and Cognitive Sciences Neurosciences Middle Aged Serious Mental Illness Anxiety Disorders subthreshold psychotic symptoms Brain Disorders Mental Health Psychotic Disorders Attention Deficit Disorder with Hyperactivity IQ attention deficit hyperactivity disorder |
| Zdroj: | Schizophrenia bulletin, vol 43, iss 5 |
| Popis: | Nearly one-third of individuals with 22q11.2 deletion syndrome (22q11.2DS) develop a psychotic disorder during life, most of them by early adulthood. Importantly, a full-blown psychotic episode is usually preceded by subthreshold symptoms. In the current study, 760 participants (aged 6-55 years) with a confirmed hemizygous 22q11.2 microdeletion have been recruited through 10 medical sites worldwide, as part of an international research consortium. Of them, 692 were nonpsychotic and with complete measurement data. Subthreshold psychotic symptoms were assessed using the Structured Interview for Prodromal Syndromes (SIPS). Nearly one-third of participants met criteria for positive subthreshold psychotic symptoms (32.8%), less than 1% qualified for acute positive subthreshold symptoms, and almost a quarter met criteria for negative/disorganized subthreshold symptoms (21.7%). Adolescents and young adults (13-25 years) showed the highest rates of subthreshold psychotic symptoms. Additionally, higher rates of anxiety disorders and attention deficit/hyperactivity disorder (ADHD) were found among the study participants with subthreshold psychotic symptoms compared to those without. Full-scale IQ, verbal IQ, and global functioning (GAF) scores were negatively associated with participants' subthreshold psychotic symptoms. This study represents the most comprehensive analysis reported to date on subthreshold psychosis in 22q11.2DS. Novel findings include age-related changes in subthreshold psychotic symptoms and evidence that cognitive deficits are associated with subthreshold psychosis in this population. Future studies should longitudinally follow these symptoms to detect whether and how early identification and treatment of these manifestations can improve long-term outcomes in those that eventually develop a psychotic disorder. |
| Databáze: | OpenAIRE |
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