Outdoor air pollution, exhaled 8-isoprostane and current asthma in adults: the EGEA study

Autor: Havet, Anaïs, Zerimech, Farid, Sanchez, Margaux, Siroux, Valérie, Le Moual, Nicole, Brunekreef, Bert, Stempfelet, Morgane, Künzli, Nino, Jacquemin, Bénédicte, Matran, Régis, Nadif, Rachel
Přispěvatelé: Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Biochimie et Biologie Moléculaire [CHRU Lille] (Pôle de Biologie Pathologie Génétique), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Epidemiology & Pulmonology [Barcelona, Spain] (ISGlobal), Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal)-Centre de Recerca en Epidemiologia Ambiental - CREAL [Barcelona, Spain]-Universitat Pompeu Fabra [Barcelona] (UPF), Equipe d’Epidémiologie Environnementale - INSERM U1209/CNRS UMR5309 (Site Santé), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Division of Occupational and Environmental Health [Utrecht, the Netherlands] (Institute for Risk Assessment - IRAS), Utrecht University [Utrecht], Julius Center for Health Sciences and Primary Care [Utrecht, the Netherlands], University Medical Center [Utrecht], Institut de Veille Sanitaire (INVS), Swiss Tropical and Public Health Institute [Basel], University of Basel (Unibas), Université de Lille, Research was funded in part by the National Hospital program of clinical research (PHRC448 national 2012, EvAdA), ANR-CES-2009, Region Nord Pas-de-Calais, Merck Sharp & Dohme (MSD), the GA2LEN project, Global Allergy and Asthma European Network, and the Fonds AGIR pour les maladies chroniques. ESCAPE (FP7/2007-2011, Grant Nr.211250). Anaïs Havet is financed by the university hospital center of Lille., European Project: 211250,EC:FP7:ENV,FP7-ENV-2007-1,ESCAPE(2008), Universitat Pompeu Fabra [Barcelona] (UPF)-Centre de Recerca en Epidemiologia Ambiental - CREAL [Barcelona, Spain]-Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: European Respiratory Journal
European Respiratory Journal, European Respiratory Society, 2018, 51 (4), Print 2018 Apr. ⟨10.1183/13993003.02036-2017⟩
European Respiratory Journal, 2018, 51 (4), Print 2018 Apr. ⟨10.1183/13993003.02036-2017⟩
ISSN: 0903-1936
1399-3003
Popis: International audience; Associations between outdoor air pollution and asthma in adults are still scarce, and the underlying biological mechanisms are poorly understood. Our aim was to study the associations between 1) long-term exposure to outdoor air pollution and current asthma, 2) exhaled 8-isoprostane (8-iso; a biomarker related to oxidative stress) and current asthma, and 3) outdoor air pollution and exhaled 8-iso.Cross-sectional analyses were conducted in 608 adults (39% with current asthma) from the first follow-up of the French case-control and family study on asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma). Data on nitrogen dioxide, nitrogen oxides, particulate matter with a diameter ≤10 and ≤2.5 µm (PM10 and PM2.5), road traffic, and ozone (O3) were from ESCAPE (European Study of Cohorts for Air Pollution Effects) and IFEN (French Institute for the Environment) assessments. Models took account of city and familial dependence.The risk of current asthma increased with traffic intensity (adjusted (a)OR 1.09 (95% CI 1.00-1.18) per 5000 vehicles per day), with O3 exposure (aOR 2.04 (95% CI 1.27-3.29) per 10 µg·m-3) and with exhaled 8-iso concentration (aOR 1.50 (95% CI 1.06-2.12) per 1 pg·mL-1). Among participants without asthma, exhaled 8-iso concentration increased with PM2.5 exposure (adjusted (a)β 0.23 (95% CI 0.005-0.46) per 5 µg·m-3), and decreased with O3 and O3-summer exposures (aβ -0.20 (95% CI -0.39- -0.01) and aβ -0.52 (95% CI -0.77- -0.26) per 10 µg·m-3, respectively).Our results add new insights into a potential role of oxidative stress in the associations between outdoor air pollution and asthma in adults.
Databáze: OpenAIRE
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