| Autor: |
Leng, T, Delowar Akther, H, Hackstein, C-P, Powell, K, King, T, Friedrich, M, Christoforidou, Z, McCuaig, S, Neyazi, M, Arancibia-Carcamo, C, Hagel, J, Powrie, F, Oxford IBD Investigators, Peres, R, Millar, V, Ebner, D, Lamichhane, R, Ussher, J, Hinks, T, Marchi, E, Willberg, C, Klenerman, P |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Popis: |
MAIT cells are an unconventional T cell population that can be activated through both TCR-dependent and TCR-independent mechanisms. Here, we examined the impact of combinations of TCR-dependent and TCR-independent signals in human CD8+ MAIT cells. TCR-independent activation of these MAIT cells from blood and gut was maximized by extending the panel of cytokines to include TNF-superfamily member TL1A. RNA-seq experiments revealed that TCR-dependent and TCR-independent signals drive MAIT cells to exert overlapping and specific effector functions, affecting both host defense and tissue homeostasis. Although TCR triggering alone is insufficient to drive sustained activation, TCR-triggered MAIT cells showed specific enrichment of tissue-repair functions at the gene and protein levels and in in vitro assays. Altogether, these data indicate the blend of TCR-dependent and TCR-independent signaling to CD8+ MAIT cells may play a role in controlling the balance between healthy and pathological processes of tissue inflammation and repair. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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