Impact of prenatal exposure to testosterone in biometrics and endocrine parameters of newborn lambs
| Autor: | Recabarren, S. E., Rojas-García, P. P., Recabarren, M. P., Norambuena, K., Sir-Petermann, T. |
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| Jazyk: | Spanish; Castilian |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Archivos de medicina veterinaria, Volume: 41, Issue: 1, Pages: 43-51, Published: 2009 ARCHIVOS DE MEDICINA VETERINARIA Artículos CONICYT CONICYT Chile instacron:CONICYT Archivos de Medicina Veterinaria; Vol. 41 Núm. 1 (2009); 43-51 |
| ISSN: | 0717-6201 0301-732X |
| Popis: | Biometric and endocrine parameters were studied in male and female Suffolk Down newborn lambs born to mothers exposed to an excess of testosterone (EPT) during 60 days (EPT-P1) and during 90 days (EPT-P2), beginning at day 30 of pregnancy. Control mothers received vegetable oil. At delivery time the following data were registered: time of delivery, number of newborns per mother and sex of the newborn. At 8 hours postpartum, the characteristics of the genitalia, the anus-urinary meatus distance and body weight were recorded. Blood samples were taken to measure cortisol, T3 and T4 on plasma. Data regarding time of birth, number of offspring and sex did not show any differences between the three groups of newborn lambs. Females born to EPT-P1 and EPT-P2 mothers exhibited masculinized genitalia, showing a penis and an empty scrotum. Females born to EPT-P1 mothers showed lower body weight and lower plasma T4 concentrations than females and males born to the other 2 groups of mothers (P < 0.05). Plasma cortisol concentrations were not different between offspring from the 3 groups of mothers, however, females born to EPT-P1 mothers showed an inverse correlation between cortisol concentration and body weight. Data showed that exposure to testosterone during a critical time during pregnancy had a profound impact on genitalia of females, and depending on the dose it produces lower body weight and lower plasma T4 concentrations in newborn females. The EPT had no effect on biometric and endocrine parameters in newborn male lambs. Se estudiaron parámetros biométricos y endocrinos de crías recién nacidas de ovejas Suffolk Down expuestas prenatalmente a un exceso de testosterona (EPT) durante 60 días (EPT-P1, n = 16) y 90 días (EPT-P2, n = 12), a partir del día 30 de preñez. Las madres control (n =32) recibieron aceite vegetal. Al momento del parto se registraron: hora delparto, número de crías por madre y sexo de las crías. Ocho horas postparto se registraron: las características de los genitales externos, distancia ano-meato urinario (DAM) y peso corporal. Se determinó concentración plasmática de cortisol, T3 y T4, por radioinmunoensayo. Hora del parto, número y sexo de las crías fue similar entre los grupos. Las hembras nacidas de madres con EPT-P1 y EPT-P2 exhibieron genitales masculinizados con presencia de un pene y un escroto vacío. Las hembras nacidas de madres EPT-P1 presentaron menor peso al nacimiento que las hembras y machos control y hembras nacidas de madres EPT-P2 (P < 0,05), DAM semejante a los machos (P |
| Databáze: | OpenAIRE |
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