The newcastle 85+ study
| Autor: | Hakeem, Sarah, Mendonça, Nuno, Aspray, Terry, Kingston, Andrew, Martin-Ruiz, Carmen, Robinson, Louise, Hill, Tom R. |
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| Přispěvatelé: | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), Comprehensive Health Research Centre (CHRC) - pólo NMS, Centro de Estudos de Doenças Crónicas (CEDOC) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| Popis: | Funding Information: Funding: The Newcastle 85+ study was jointly funded by the Medical Research Council and Biotechnology and Biomedical Science Research Council (G0500997), now part of UK Research and Innovation (UKRI) in addition to the Newcastle Healthcare Charity. The following waves were funded by the Dunhill Medical Trust (R124/0509), Newcastle University, UK Medical Research Council and the British Heart Foundation. Overall, the project was supported by National Institute for Health Research Newcastle Biomedical Research Centre based at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University. This particular analysis (vitamin D and telomere length) received no additional external funding. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. (1) Introduction: vitamin D may maintain the telomere length, either directly or via the inflammation effect and/or modulating the rate of cell proliferation. Whilst results from crosssectional studies investigating the association between 25(OH)D concentration and telomere length have been mixed, there is a dearth of data from prospective studies which have assessed these associations. This study aimed to examine the association between 25(OH)D concentration in plasma and telomere length in blood cells in very-old adults (≥85 years old) at baseline, 18 months and 36 months by controlling for related lifestyle factors. (2) Methodology: our prospective cohort study comprised 775 participants from the Newcastle 85+ Study who had 25(OH)D measurements at baseline. Plasma 25(OH)D was stratified as 50 nmol/L (high). Peripheral blood mononuclear cell telomere length was measured by quantitative real-time polymerase chain reaction at baseline, 18 and 36 months from baseline. (3) Results: a positive significant association was found between 25(OH)D concentration and telomere length amongst very-old participants at baseline (95% CI = 12.0–110.3, B = 61.2 ± 5.0, p = 0.015). This association was negative at 18 months (95% CI = −59.9–−7.5, B = −33.7 ± 13.3, p = 0.012) but was non-significant at 36 months. (4) Conclusion: Circulating 25(OH)D concentration shows inconsistent relationships with telomere length over time in very-old (85+ year old) adults. publishersversion published |
| Databáze: | OpenAIRE |
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