Brain glucose metabolism and cognitive function in patients with amnestic Mild Cognitive Impairment (MCI)

Autor: Nobili, FLAVIO MARIANO, Pagani, M., Salmaso, D., Piccardo, A., Morbelli, S., Girtler, NICOLA GIOVANNI, Bianchi, P., Villavecchia, G., Rodriguez, Guido
Rok vydání: 2006
Předmět:
Zdroj: European journal of nuclear medicine and molecular imaging
33S2 (2006): s156.
info:cnr-pdr/source/autori:Nobili F, Pagani M, Salmaso D, Piccardo A, Morbelli S, Girtler N, Bianchi P, Villavecchia G, Rodriguez G/titolo:Brain glucose metabolism and cognitive function in patients with amnestic Mild Cognitive Impairment (MCI)/doi:/rivista:European journal of nuclear medicine and molecular imaging (Print)/anno:2006/pagina_da:s156/pagina_a:/intervallo_pagine:s156/volume:33S2
Popis: Aim: The need of early diagnosis of Alzheimer’s disease before the onset of dementia comes from the several ongoing phase 3 pharmacological studies that will hopefully lead to effective pathogenetic treatment of the disease in the next few years. In this frame, both brain PET and neuropsychological assessment are under extensive evaluation. Methods: Twenty-one consecutive patients (9 males; mean age:76.5±5.9; mean MMSE score:27.8±1.5) with amnestic MCI (criteria of the European Alzheimer’s Disease Consortium, JNNP 2006, in press), underwent 18FDG-PET (GE Advance), 2D acquisition, OSEM reconstruction (16 subset, 2 iterations). Ten normal subjects (2 males; mean age:70.4±7.3; mean MMSE score:28.7±1.3) were recruited as control group (CTR). Neuropsychological evaluation included tests for ideomotor speed and shifting attention (trailmaking A and B), categorial verbal fluency, logic reasoning (Raven’s PM38), episodic verbal memory (Buschke), spatial memory (digit symbol), visuospatial abilities (constructional apraxia and clock drawing), cognitive flexibility (Stroop colour-word). PET data were analysed by a 3-D computerized brain atlas and 27 Brodmann areas (BA) bilaterally were submitted to ANCOVA. Step-wise discriminant analysis assessed the concordance between PET data and clinical diagnosis. Results: Overall PET analysis showed significant group (p
Databáze: OpenAIRE
Externí odkaz: