NMR-based metabolomics for identification of α-amylase inhibitors in rowan berries (Sorbus spp.)
| Autor: | Broholm, Sofie L., Simone Gramsbergen, Nils Nyberg, Anna Jäger, Dan Staerk |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Zdroj: | Broholm, S L, Gramsbergen, S, Nyberg, N, Jäger, A & Stærk, D 2015, ' NMR-based metabolomics for identification of α-amylase inhibitors in rowan berries ( Sorbus spp.) ', 36th Danish NMR Meeting, Lund, Sweden, 19/01/2015-20/01/2015 . University of Copenhagen |
| Popis: | Type 2 diabetes is a metabolic disorder estimated to affect millions of people all over the world.1 One way of reducing diabetes-related complications is to controlpostprandial glucose.2 Inhibition of the carbohydrate digestive enzyme α-amylase is a therapeutic target for maintaining low blood glucose levels. A study from 2011shows that berries from Sorbus spp (rowan berries) effectively inhibit α-amylase activity and suggests that the active compounds are proanthocyanidins.3 The aim of thisproject is to identify the rowan berry species with highest α-amylase inhibitory activity - and to find a 1H-NMR method suitable for NMR-based metabolomics |
| Databáze: | OpenAIRE |
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