[Molecular epidemiology of HIV-1 strains in the Moscow Region]
| Autor: | Gilyazova, A. V., Zenin, P. V., Pronin, A. Yu, Serkov, I. L., Khametova, K. M., Orlova-Morozova, E. A., Zhukova, E. V., Kornilaeva, G. V., Pasternak, A. O., Lukashov, V. V., E.V. Karamov |
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| Přispěvatelé: | Amsterdam institute for Infection and Immunity, Medical Microbiology and Infection Prevention, Amsterdam Public Health |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Voprosy virusologii, 55(5), 25-29. Izdatelstvo Meditsina Scopus-Elsevier |
| ISSN: | 0507-4088 |
| Popis: | The Moscow Region is one of the HIV-1-affected subjects of the Russian Federation; there were 34613 HIV-1-infected subjects as of October 31, 2009. To characterize the molecular epidemiology of HIV-1 in the Moscow Region, the investigators obtained and studied HIV-1 variants from 61 infected subjects of the region, who were major risk groups: intravenous drug users (IDUs) and hetero- and homosexually infected persons. Genetic analysis of HIV-1 variants was carried out by sequencing the gag genes (729 nucleotides in length, including full-length protein p17 and partial p24) andlor env (270 nucleotides in length, V3 region) with further phylogenetic analysis. The findings demonstrated that HIV-1 subtype A variants are dominant in the Moscow Region and detectable in 93.5% of IDUs and 100% of heterosexually infected persons. Phylogenetically (and accordingly epidemiologically) unrelated HIV-1 subtype B strains were revealed in 4 patients, including 2 IDUs |
| Databáze: | OpenAIRE |
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