Synthesis, self-assembly and controlled drug delivery of novel thermo-responsive and amphiphilic block copolymers based on polylactide, polyacrylamide and poly(oligo(ethylene glycol) methacrylate)

Autor: Hu, Yanfei
Přispěvatelé: Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Université Montpellier, Suming Li, Vincent Darcos
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Human health and pathology. Université Montpellier, 2015. English. ⟨NNT : 2015MONT3502⟩
Popis: Two series of thermo-responsive and amphiphilic triblock copolymers, i.e. poly(L-lactide)/poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) and poly(L-lactide)/poly(2-(2-methoxyethoxy) ethyl methacrylate-co-oligo(ethylene glycol) methacrylate) were synthesized by atom transfer radical polymerization using Br-PLLA-Br as macroinitiator under mild conditions. The obtained copolymers present well defined chain structures with narrow dispersity, and are able to self-assemble in aqueous medium yielding spherical micelles with size below 100 nm and low critical micellization concentration (
Databáze: OpenAIRE