Innate immunity in the control of HIV/AIDS
| Autor: | Ploquin, Mickaël J.-Y., Jacquelin, Béatrice, Jochems, Simon, Barré-Sinoussi, Françoise, Müller-Trutwin, Michaela |
|---|---|
| Přispěvatelé: | Régulation des Infections Rétrovirales, Institut Pasteur [Paris], Université Paris Diderot - Paris 7 (UPD7), Institut Pasteur [Paris] (IP) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
MESH: HIV-1/immunology
simian immunodeficiency virus MESH: Humans dendritic cell animal diseases virus diseases HIV MESH: Cytokines/immunology MESH: HIV Infections/immunology interferon biochemical phenomena metabolism and nutrition natural killer cell [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity MESH: Toll-Like Receptors/immunology MESH: Killer Cells Natural/immunology MESH: Dendritic Cells/immunology [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology bacteria [SDV.IMM]Life Sciences [q-bio]/Immunology MESH: Immunity Innate innate immunity MESH: Adaptive Immunity |
| Zdroj: | AIDS AIDS, Lippincott, Williams & Wilkins, 2012, 26 (10), pp.1269-1279. ⟨10.1097/QAD.0b013e328353e46b⟩ AIDS. Official journal of the international AIDS Society AIDS. Official journal of the international AIDS Society, 2012, 26 (10), pp.1269-1279. ⟨10.1097/QAD.0b013e328353e46b⟩ |
| ISSN: | 0269-9370 1473-5571 |
| DOI: | 10.1097/QAD.0b013e328353e46b⟩ |
| Popis: | International audience; From the publication of the first AIDS issue onwards, major advances have been made in the field of innate immunity during HIV infection. Innate immunity can be defined as the first and unspecific lines of defense constitutively present and ready to be mobilized upon infection. Although a large body of literature adamantly highlights that innate immunity is a critical weapon of defense against HIV and its simian parents (simian immunodeficiency virus, SIV), innate immunity is still underexplored. Focusing on innate immunity may open new paths for the development of innovative therapeutics and vaccine strategies against HIV. Understanding innate immunity may shed light on the natural protection occurring in rare HIV-1-infected individuals who control their infection. This review focuses on innate mechanisms sensing HIV-1 entry and controlling HIV-1 infection, as well as promoting inflammation and shaping adaptive immunity. |
| Databáze: | OpenAIRE |
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