DNA structures decorated with cathepsin G/secretory leukocyte proteinase inhibitor stimulate IFNI production by plasmacytoid dendritic cells
| Autor: | Skrzeczyńska-Moncznik, Joanna, Wlodarczyk, Agnieszka, Banaś, Magdalena, Kwitniewski, Mateusz, Zabiegło, Katarzyna, Kapińska-Mrowiecka, Monika, Dubin, Adam, Cichy, Joanna |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Skrzeczynska-Moncznik, J, Wlodarczyk, A, Banas, M, Kwitniewski, M, Zabieglo, K, Kapinska-Mrowiecka, M, Dubin, A & Cichy, J 2013, ' DNA structures decorated with cathepsin G/secretory leukocyte proteinase inhibitor stimulate IFNI production by plasmacytoid dendritic cells ', American journal of clinical and experimental immunology, vol. 2, no. 2, pp. 186-94 . |
| Popis: | Plasmacytoid dendritic cells (pDCs) and neutrophils are detected in psoriatic skin lesions and implicated in the pathogenesis of psoriasis. pDCs specialize in the production of type I interferon (IFNI), a cytokine that plays an important role in chronic autoimmune-like inflammation, including psoriasis. Here, we demonstrate that IFNI production in pDCs is stimulated by DNA structures containing the neutrophil serine protease cathepsin G (CatG) and the secretory leukocyte protease inhibitor (SLPI), which is a controlling inhibitor of serine proteases. We also demonstrate the presence of neutrophil-derived DNA structures containing CatG and SLPI in lesional skin samples from psoriasis patients. These findings suggest a previously unappreciated role for CatG in psoriasis by linking CatG and its inhibitor SLPI to the IFNI-dependent regulation of immune responses by pDCs in psoriatic skin. |
| Databáze: | OpenAIRE |
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