Base deficit as an early marker of coagulopathy in trauma
| Autor: | Cheddie, S, Muckart, D J J, Hardcastle, T C |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Zdroj: | South African Journal of Surgery; Vol 51, No 3 (2013); 88-91 South African Journal of Surgery, Volume: 51, Issue: 3, Pages: 88-90, Published: 2013 |
| ISSN: | 0038-2361 2078-5151 |
| Popis: | Background. The acute coagulopathy of trauma is associated with hypoperfusion, metabolic acidosis and an increased mortality rate. Biochemical markers of hypoperfusion, namely base deficit (BD) and lactate, are commonly used to assess the degree of hypoperfusion. Early identification of hypoperfusion and acidosis using BD and lactate may help predict the development of coagulopathy in trauma patients and direct therapy.Objectives. To identify whether a correlation exists between BD, lactate, injury severity, early-onset coagulopathy and mortality.Methods. A retrospective chart analysis was undertaken of patients transferred directly from scene to the level I trauma unit at Inkosi Albert Luthuli Central Hospital, Durban, South Africa, from 2007 to 2008. Patients with evidence of hypoperfusion were selected. Hypoperfusion was defined as a base deficit >-2 and coagulopathy as an International Normalized Ratio (INR) of >1.2. BD, lactate, chloride, temperature, Injury Severity Score (ISS), INR and mortality were recorded in this cohort. Student’s t-test and Fisher’s exact test were used for continuous and categorical variables, respectively. Correlation curves were used to determine the degree of association between the variables BD, lactate and ISS with respect to the INR. A p-value of |
| Databáze: | OpenAIRE |
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