| Autor: |
Lolkema, M.P.J.K., Mans, D.A., Snijckers, C.M.J.T., Noort, Mascha van, Beest, M. van, Voest, E.E., Giles, R.H. |
| Jazyk: |
angličtina |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
FEBS letters, 581(24), 4571. Elsevier |
| ISSN: |
0014-5793 |
| Popis: |
Synthesis and maintenance of primary cilia are regulated by the von Hippel-Lindau (VHL) tumour suppressor protein. Recent studies indicate that this regulation is linked to microtubule-dependent functions of pVHL such as orienting microtubule growth and increasing plus-end microtubule stability, however little is known how this occurs. We have identified the kinesin-2 motor complex, known to regulate cilia, as a novel and endogenous pVHL binding partner. The interaction with kinesin-2 facilitates pVHL binding to microtubules. These data suggest that microtubule-dependent functions of pVHL are influenced by kinesin-2. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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