Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates

Autor: Dudley, Dawn M, Van Rompay, Koen K, Coffey, Lark L, Ardeshir, Amir, Keesler, Rebekah I, Bliss-Moreau, Eliza, Grigsby, Peta L, Steinbach, Rosemary J, Hirsch, Alec J, MacAllister, Rhonda P, Pecoraro, Heidi L, Colgin, Lois M, Hodge, Travis, Streblow, Daniel N, Tardif, Suzette, Patterson, Jean L, Tamhankar, Manasi, Seferovic, Maxim, Aagaard, Kjersti M, Martín, Claudia Sánchez-San, Chiu, Charles Y, Panganiban, Antonito T, Veazey, Ronald S, Wang, Xiaolei, Maness, Nicholas J, Gilbert, Margaret H, Bohm, Rudolf P, Adams Waldorf, Kristina M, Gale, Michael, Rajagopal, Lakshmi, Hotchkiss, Charlotte E, Mohr, Emma L, Capuano, Saverio V, Simmons, Heather A, Mejia, Andres, Friedrich, Thomas C, Golos, Thaddeus G, O'Connor, David H
Rok vydání: 2018
Předmět:
Zdroj: Nature medicine, vol 24, iss 8
Popis: Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here, we found that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite showing few clinical signs of infection. Pregnancy loss due to asymptomatic ZIKV infection may therefore be a common but under-recognized adverse outcome related to maternal ZIKV infection.
Databáze: OpenAIRE