Using intra-articular tranexamic acid in total knee replacement surgery with and without bleeding control: a prospective randomized double blind study

Autor: Arslan, Aydın, Görmeli, Gökay
Přispěvatelé: İstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Gormeli, Gokay
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Popis: OBJECTIVE: To investigate the effectiveness of tranexamic acid (TA) application in two techniques: in the first one wound closure is performed before the tourniquet is released; in the second one, wound closure is performed after the tourniquet is released. PATIENTS AND METHODS: The study is conducted on four groups of patients: (1) TA + TNR (tourniquet not released) where there is no bleeding control and TA is applied after wound closure without tourniquet release; (2) TA - TNR where placebo is applied after wound closure without tourniquet release; (3) TA + TR (tourniquet released) where tourniquet is released first and TA is applied after bleeding control and wound closure; and (4) TA - TR where tourniquet release is followed by bleeding control and placebo application. RESULTS: The amount of hemorrhage in hemovac drains in each group was as follows: 217.4 +/- 99.6 (100-590) ml in the TA + TNR group; 411.6 +/- 133.7 (175-850) ml in the TA - TNR group; 291.2 +/- 89.5 (160-650) ml in the TA + TR group; and 458.2 +/- 138.6 (200-920) ml in the TA - TR group (p
Databáze: OpenAIRE